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TranscriptomicsCOUP-TFII regulates human endometrial stromal genes involved in inflammation
Although the function of COUP-TFII in uterine decidualization has been described in mice, its role in the human uterus remains unknown.To interrogate the role of COUP-TFII in human endometrial function, we utilized a siRNA-mediated loss of function approach in primary human endometrial stromal cells...
ORGANISM(S): Homo sapiens 
2014-01-07 | E-GEOD-47052 | biostudies-arrayexpress
TranscriptomicsAn improved method for the isolation of endometrial epithelial and stromal cells from the total hysterectomy specimen
We aimed to improve the efficiency of isolating endometrial epithelial and stromal cells (EMECs and EMSCs) from hysterectomy specimens. We revealed by immunohistochemical staining that the large tissue fragments remaining after collagenase treatment, which are usually discarded after the first filtr...
ORGANISM(S): Homo sapiens 
2016-06-14 | E-GEOD-73090 | biostudies-arrayexpress
TranscriptomicsReciprocal communication between endometrial stromal cells and macrophages
Endometriosis is an inflammatory disease and bone marrow-derived cells are abundant in endometriotic lesions and in the peritoneal fluid of women with the disease. This study tested the hypothesis that reciprocal communication occurs between macrophages and cultured human endometrial stromal cells ...
ORGANISM(S): Homo sapiens 
2010-07-21 | E-GEOD-19834 | biostudies-arrayexpress
TranscriptomicsPER2 synchronizes mitotic expansion and decidual transformation of human endometrial stromal cells
Implantation is dependent on synchronized interactions between the conceptus and surrounding decidual cells but the involvement of clock genes in this process is not well understood. Circadian oscillations are predicated on transcriptional-translational feedback loops, which balance the activities o...
ORGANISM(S): Homo sapiens 
2015-09-16 | E-GEOD-62854 | biostudies-arrayexpress
TranscriptomicsUterine stromal cell_cultured with uNK conditioned Medium
The endometrium contains a distinct population of immune cells consisting of 70% natural killer (NK) cells that undergo cyclic changes during the menstrual cycle. However, how these uterine NK (uNK) cells interact with uterine stromal cells (SC) remains unclear. We therefore investigated the paracri...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-9718 | biostudies-arrayexpress
GenomicsGenome-wide analysis of histone modifications in human endometrial stromal cells [ChIP-Seq]
Dramatic changes of gene expressions are known to occur in human endometrial stromal cells (ESC) during decidualization. The changes in gene expression are associated with changes of chromatin structure, which are regulated by epigenetic mechanisms such as histone modifications. Here, we investiga...
ORGANISM(S): Homo sapiens 
2015-03-03 | E-GEOD-57007 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of human endometrial stromal cells transduced with BMP2- and WNT4-adenovirus.
Our previous studies have shown that bone morphogenetic protein 2 (BMP2), a morphogen belonging to the TGFM-NM-2 superfamily, is markedly induced in human primary endometrial stromal cells (HESC) as they undergo differentiation in response to steroid hormones and cAMP. WNT4 is a downstream target of...
ORGANISM(S): Homo sapiens 
2013-02-08 | E-GEOD-39949 | biostudies-arrayexpress
ProteomicsDeep quantitative proteomics underlies extensive metabolic reprogramming and cancer-like changes of ectopic endometriotic stromal cells
Endometriosis is a prevalent health condition in women of reproductive age characterized by ectopic growth of endometrial tissue in the extrauterine environment. Thorough understanding of the molecular mechanisms underlying the disease are still lacking and incomplete. We dissect eutopic and ectopic...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-22 | MSV000080276 | MassIVE
TranscriptomicsGenome-wide analysis of histone modifications in human endometrial stromal cells [RNA-Seq]
Dramatic changes of gene expressions are known to occur in human endometrial stromal cells (ESC) during decidualization. The changes in gene expression are associated with changes of chromatin structure, which are regulated by epigenetic mechanisms such as histone modifications. Here, we investiga...
ORGANISM(S): Homo sapiens 
2015-03-03 | E-GEOD-57009 | biostudies-arrayexpress
TranscriptomicsExpression data of PGR isoforms, PRA and PRB, regulated genes in differentiating human endometrial stromal cells
gene expression at 6h of differentiation of Human endometrial stromal cell expressing either or both of PRA and PRB Endogenous PGR expression is silenced with siRNA mediated knockdown. Then, cells are transduced with adenovirus exressing flag tagged PRA or flag tagged PRB. Human endometrial stromal ...
ORGANISM(S): Homo sapiens 
2015-04-27 | E-GEOD-48853 | biostudies-arrayexpress
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