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TranscriptomicsTranscriptomic analysis of cultured corneal endothelial cells as a validation for their use in cell-replacement therapy
The corneal endothelium plays a primary role in maintaining corneal homeostasis and clarity, and must be surgically replaced with allogenic donor corneal endothelium in the event of visually significant dysfunction. However, a worldwide shortage of donor corneal tissue has led to a search for altern...
ORGANISM(S): Homo sapiens 
2015-09-04 | E-GEOD-65991 | biostudies-arrayexpress
ProteomicsProteomics in exploring the endothelial dysfunction mechanism induced by serum exosomes from diabetic retinopathy and diabetic nephropathy patients
In this study, we used human glomerular endothelial cells (HGECs) as cells model, proteomics TMT-based LC-MS/MS was employed to discover the underlying mechanisms of endothelial dysfunction caused by SExos from diabetic retinopathy and nephropathy patients.
ORGANISM(S): Homo Sapiens 
2021-12-29 | PXD030660 |
TranscriptomicsRole of zyxin in the tension-induced expression change in endothelial cells
One of the hallmarks in hypertension is a pressure-induced change in endothelial cell phenotype. A cytoskeletal protein zyxin, which was seen to translocate from focal adhesion contacts to the nucleus in response to the increased wall tensionis, mediates the tension-induced endothelial signaling. Mi...
ORGANISM(S): Homo sapiens 
2010-08-16 | E-GEOD-17814 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression between Human umbilical vein endothelial cells and Human liver sinusoidal endothelial cells
To identify leukocyte adhesion receptors which differentially regulate recruitment in human liver sinusoidal endothelial cells compared to a protoptypic venular endothelium Gene expression was measured in four groups Group 1: cultured human liver sinusoidal endothelial cells (HSEC) Group 2: cultured...
ORGANISM(S): Homo sapiens 
2016-10-24 | E-GEOD-78020 | biostudies-arrayexpress
TranscriptomicsLPS response of cardiovascular endothelial cells transduced with an APEX1(1-20) expressing vector or an empty vector
Sepsis is an exaggerated immune response upon infection with lipopolysaccharide (LPS) as the main causative agent. LPS-induced activation and apoptosis of endothelial cells (EC) can lead to organ dysfunction and finally organ failure. We have previously demonstrated that the first twenty amino acid...
ORGANISM(S): Homo sapiens 
2021-09-20 | E-MTAB-10936 | biostudies-arrayexpress
TranscriptomicsTranscription Profiling of Human Aortic Endothelial Cells After Treatment with Interferon-Alpha
Systemic Lupus Erythematosus is associated with an increased risk of cardiovascular disease (CVD). Interferon-response genes have been associated with endothelial dysfunction in SLE patients. The aim of this study is to identify the effects of IFN-alpha on human endothelial cells in order to deter...
ORGANISM(S): Homo sapiens 
2013-09-11 | E-MEXP-3746 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human coronary artery endothelial cells treated with ADMA at 2uM (a pathophysiological dose) and 100uM (a pharmacological dose), for 24h
Asymmetric dimethylarginine (ADMA) is a naturally occurring inhibitor of nitric oxide synthesis that accumulates in wide range of diseases associated with endothelial dysfunction and enhanced atherosclerosis. Plasma ADMA has been implicated as a major novel cardiovascular risk factor, but the mechan...
ORGANISM(S): Homo sapiens 
2005-09-01 | E-MEXP-377 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of synectin knock-out mouse primary endothelial cells before and after FGF2 induction
Transcriptional regulatory effects of synectin deletion in murine primary endothelial cells both before and after FGF2 induction.
ORGANISM(S): Mus musculus 
2006-10-01 | E-MEXP-820 | biostudies-arrayexpress
TranscriptomicsInvestigation of endothelial cell gene dysregulation in early pulmonary arterial hypertension disease model
Endothelial cell (EC) dysfunction plays a key role in the pathogenesis of pulmonary arterial hypertension (PAH). To avoid cell cultures and whole lung tissue samples, we have, for the first time, used CD31 antibody coated magnetic beads in conjunction with genome scale RNA expression microarrays to ...
ORGANISM(S): Rattus norvegicus 
2014-02-06 | E-GEOD-42767 | biostudies-arrayexpress
TranscriptomicsEffects of BMPR2 Loss in Human Pulmonary Artery Endothelial Cells
Pulmonary arterial hypertension (PAH) is a fatal disease characterized by a proliferative endothelial cell phenotype, inflammation and pulmonary vascular remodeling. BMPR2 loss-of-function has been linked to pathologic plexiform lesions with obliteration of distal pulmonary arteries distal pulmonary...
ORGANISM(S): Homo sapiens 
2015-12-04 | E-GEOD-70456 | biostudies-arrayexpress
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