Endothelial-mesenchymal transition

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Cardiomyocyte-Derived HSPB1 Regulates TGF-β1 Maturation and Inhibits Endothelial-to-Mesenchymal Transition in Myocardial Fibrosis after Infarction

Myocardial fibrosis is a major contributor to heart failure after myocardial infarction (MI), primarily driven by endothelial-to-mesenchymal transition (EndoMT). Heat shock protein B1 (HSPB1) has cardioprotective functions, but its role in MI-induced fibrosis remains unclear. Here, we show that card...

ORGANISM(S): Homo Sapiens

2025-12-22 | PXD072325 |

Transcriptome profiling of human endothelial cells undergoing endothelial-to-mesenchymal transition

PRJNA992092 | ENA

Secretomes from non-small cell lung cancer cells induce endothelial plasticity through a partial endothelial-to-mesenchymal transition

The tumor microenvironment (TME) of non-small cell lung cancer (NSCLC) is highly heterogeneous and is involved in tumorigenesis and resistance to therapy. Among the cells of the TME, endothelial cells are associated with the latter processes through endothelial-to-mesenchymal transition (EndMT). Dur...

ORGANISM(S): Homo sapiens (Human)

2025-04-24 | PXD054295 | Pride