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MetabolomicsIsoquercitrin alleviates subchronic high-altitude hypoxia-induced myocardial injury by regulating mitochondrial energy metabolism and maintaining immune–inflammatory homeostasis
High-altitude hypoxia induces myocardial metabolic disorders, structural remodeling, and functional impairment, which threaten the health of highland populations. The interventional effects and molecular mechanisms of isoquercitrin (IQ), a natural flavonoid with cardiovascular protective activity, a...
2026-07-29 | MTBLS15192 | MetaboLights
MetabolomicsEnergy-stress-mediated AMPK activation inhibits ferroptosis

Energy stress depletes ATP and induces cell death. Here we identify an unexpected inhibitory role of energy stress on ferroptosis, a form of regulated cell death induced by iron-dependent lipid peroxidation. We found that ferroptotic cell death and lipid peroxidation can be inhibited by treatment...

2023-01-31 | MTBLS1399 | MetaboLights
TranscriptomicsRegulation of hypothalamic gene expression by glucocorticoid: implications for energy homeostasis
The current study has investigated the hypothalamic gene expressions regulated by glucocorticoid (GC), key hormones in energy homeostasis. Using serial analysis of gene expression (SAGE) method, we have studied the effects of adrenalectomy (ADX) and GC on the transcriptomes of mouse hypothalamus. Ap...
ORGANISM(S): Mus musculus 
2006-09-22 | E-GEOD-3366 | biostudies-arrayexpress
MetabolomicsCD36 palmitoylation regulates the lipid metabolic homeostasis

Alterations in myocardial energy substrate metabolism following myocardial infarction (MI) results in structural and functional abnormalities of the heart. The fatty acid translocase CD36 (CD36), acrucial membrane protein, plays a pivotal role in regulating fatty acid (FA) uptake and lipid homeos...

2025-06-15 | MTBLS12600 | MetaboLights
ProteomicsDisruption of STIM1-mediated Ca2+ sensing and energy metabolism in adult skeletal muscle compromises exercise tolerance, proteostasis and lean mass
STIM1 is a single-pass transmembrane endoplasmic/sarcoplasmic reticulum (E/SR) protein recognized for its role in store operated Ca2+ entry (SOCE), an ancient and ubiquitous signaling pathway. Whereas STIM1 is indispensable during development, its biological and metabolic functions in mature muscle ...
ORGANISM(S): Mus Musculus (mouse) 
2021-12-30 | PXD030674 | JPOST Repository
MetabolomicsClostridium bolteae suppresses Enterobacteriaceae expansion and restores gut microbiome homeostasis via disrupting siderophore-mediated iron acquisition

Intestinal inflammation and the related gut microbiome dysbiosis are becoming prevalent worldwide. Overgrowth of Enterobacteriaceae exacerbates intestinal inflammation and gut microbiome dysbiosis. Enterobacteriaceae secrets siderophore to acquire iron and survive in the iron-limited gut. Therefo...

2026-01-03 | MTBLS13592 | MetaboLights
MetabolomicsCXCL12 and MYC control energy metabolism to support adaptive responses after kidney injury
Kidney injury is a common complication of severe disease. Here, we report that injuries of the zebrafish embryonal kidney are rapidly repaired by a migratory response in 2-, but not in 1-day-old embryos. Gene expression profiles between these two developmental stages identify cxcl12a and myca as can...
2018-10-11 | MTBLS723 | MetaboLights
MetabolomicsLactiplantibacillus plantarum PS128 restores microbiota-driven polyamine homeostasis to alleviate autism-like behaviors in Fmr1 knockout mice

Background Autism spectrum disorder (ASD) is biologically heterogeneous and has limited mechanism-informed interventions targeting core behavioral symptoms. Emerging evidence suggests that gut microbial metabolism shapes neurobehavioral outcomes, yet the specific metabolic pathwa...

2026-02-06 | MTBLS13859 | MetaboLights
TranscriptomicsExpression data from synchronized L4 C. elegans during starvation
The endoplasmic reticulum (ER) is an organelle associated with lipid metabolism. However, the involvement of the ER in nutritional status-dependent energy homeostasis is largely unknown. The results of this study demonstrate that IRE-1, an ER protein known to be involved in the unfolded protein resp...
ORGANISM(S): Caenorhabditis elegans 
2010-05-08 | E-GEOD-15656 | biostudies-arrayexpress
MetabolomicsZEB1 Maintains Energy Metabolism to Sustain Cardiac Function Through Synergistic Regulation with TEAD1
Metabolic reprogramming plays a critical role in heart failure (HF), but its regulatory mechanisms remain incompletely understood. Zinc finger E-box binding homeobox 1 (ZEB1), a transcription factor initially identified as a regulator of epithelial-mesenchymal transition, has recently been implicate...
2026-09-28 | MTBLS15833 | MetaboLights
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