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MetabolomicsMetabolomic Analysis of Fission Yeast at the Onset of Nitrogen Starvation
Microorganisms naturally respond to changes in nutritional conditions by adjusting their morphology and physiology. The cellular response of the fission yeast S. pombe to nitrogen starvation has been extensively studied. Here, we report time course metabolomic analysis during one hour immediately af...
2013-11-26 | MTBLS67 | MetaboLights
MetabolomicsSpecific biomarkers for stochastic division patterns and starvation-induced quiescence under limited glucose levels in fission yeast
Glucose as a source of energy is centrally important to our understanding of life. We investigated the cell division-quiescence behavior of the fission yeast Schizosaccharomyces pombe under a wide range of glucose concentrations (0-111 mM). The mode of S. pombe cell division under a microfluidic per...
2017-07-06 | MTBLS316 | MetaboLights
Metabolomicsα-ketoglutarate maintains AMPK translation for energy sensing in human cancer cells_lipid

The energy sensor AMPK promotes tumor cell survival under stress, but how to prevent AMPK activation to blunt tumor progression remains unclear. Here we show that the metabolite α-ketoglutarate (α-KG) controls AMPK translation through a TET-YBX1 axis, which can be exploited to sensitize human can...

2025-07-17 | MTBLS12741 | MetaboLights
Metabolomicsα-ketoglutarate maintains AMPK translation for energy sensing in human cancer cells_targeted metabolites

The energy sensor AMPK promotes tumor cell survival under stress, but how to prevent AMPK activation to blunt tumor progression remains unclear. Here we show that the metabolite α-ketoglutarate (α-KG) controls AMPK translation through a TET-YBX1 axis, which can be exploited to sensitize human can...

2025-07-16 | MTBLS12731 | MetaboLights
Metabolomicsα-ketoglutarate maintains AMPK translation for energy sensing in human cancer cells_untargeted metabolites_flux_FAO

The energy sensor AMPK promotes tumor cell survival under stress, but how to prevent AMPK activation to blunt tumor progression remains unclear. Here we show that the metabolite α-ketoglutarate (α-KG) controls AMPK translation through a TET-YBX1 axis, which can be exploited to sensitize human can...

2025-07-17 | MTBLS12738 | MetaboLights
TranscriptomicsExpression data from synchronized L4 C. elegans during starvation
The endoplasmic reticulum (ER) is an organelle associated with lipid metabolism. However, the involvement of the ER in nutritional status-dependent energy homeostasis is largely unknown. The results of this study demonstrate that IRE-1, an ER protein known to be involved in the unfolded protein resp...
ORGANISM(S): Caenorhabditis elegans 
2010-05-08 | E-GEOD-15656 | biostudies-arrayexpress
TranscriptomicsRNA seq of MLL-ENL transformed cells under serine/glycine starvation including a starvation resistant clone
Primary hematopoietic cells were transformed by retrovirally transduced MLL-ENL. The resulting cell population was either cultured in full medium or under starvation conditions without serine and glycine. In addition a spontaneously arising ser/gly starvation resistant clone was included in this exp...
ORGANISM(S): Mus musculus 
2021-06-21 | E-MTAB-8738 | biostudies-arrayexpress
TranscriptomicsE. coli Isoleucine starvation and stringent response network
Transcription profiling of wild type, relA-, and relA-spoT-, crp-, dksA-, rpoS-, lrp- mutant strains of E. coli starved for isoleucine Bacteria comprehensively reorganize their global gene expression when faced with nutrient exhaustion. In Escherichia coli and other free-living bacteria, the alarmo...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2008-04-08 | E-GEOD-11087 | biostudies-arrayexpress
TranscriptomicsExtreme calorie restriction and energy source starvation in Saccharomyces cerevisiae represent distinct physiological states
Cultivation methods used to investigate microbial calorie restriction often result in carbon and energy starvation. This study aims to dissect cellular responses to calorie restriction and starvation in Saccharomyces cerevisiae by using retentostat cultivation. In retentostats, cells are continuousl...
ORGANISM(S): Saccharomyces cerevisiae 
2011-08-15 | E-GEOD-22602 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rice suspension cells under sucrose starvation
Sugar is an important resource for energy generation and developmental regulation in plants, and sucrose starvation causes enormous changes in cellular morphology, enzyme activities and gene expression. Genome-wide gene expression profiling provides a comprehensive knowledge into gene expression un...
ORGANISM(S): Oryza sativa 
2008-06-14 | E-GEOD-5853 | biostudies-arrayexpress
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