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UnknownA Systems Pharmacology Approach Uncovers Wogonoside as an Angiogenesis Inhibitor of Triple-Negative Breast Cancer by Targeting Hedgehog Signaling.
Not available
S-EPMC6697584 | biostudies-literature
UnknownPersonal Mutanomes Meet Modern Oncology Drug Discovery and Precision Health.
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S-EPMC6294046 | biostudies-literature
UnknownMy personal mutanome: a computational genomic medicine platform for searching network perturbing alleles linking genotype to phenotype.
Not available
S-EPMC7845113 | biostudies-literature
UnknownCryo-EM Structures Reveal Mechanism and Inhibition of DNA Targeting by a CRISPR-Cas Surveillance Complex.
Not available
S-EPMC5683424 | biostudies-literature
UnknownMatrix stiffening promotes a tumor vasculature phenotype.
Not available
S-EPMC5255592 | biostudies-literature
UnknownTarget identification among known drugs by deep learning from heterogeneous networks.
Not available
S-EPMC8150105 | biostudies-literature
TranscriptomicsIdentification of Neuronal RNA Targets of TDP-43-Containing Ribonucleoprotein Complexes
We identify the RNA targets of TAR DNA-binding protein 43 (TDP-43) from cortical neurons by RNA immunoprecipitation followed by deep sequencing (RIP-seq). We identify 4352 highly enriched RNA targets of TDP-43. We determined that the canonical TDP-43 binding site (TG)n was 55.1-fold enriched in our ...
ORGANISM(S): Rattus norvegicus 
2010-11-04 | E-GEOD-25032 | biostudies-arrayexpress
UnknownGenome-wide association study and admixture mapping identify different asthma-associated loci in Latinos: the Genes-environments & Admixture in Latino Americans study.
Not available
S-EPMC4085159 | biostudies-literature
GenomicsHaploinsufficiency of an RB-E2F1-Condensin II complex causes replication stress and contributes to mesenchymal cancers [γH2AX localization]
Genome instability is a characteristic of malignant cells, however, evidence for its contribution to tumorigenesis has been enigmatic. In this study we demonstrate that a complex containing the retinoblastoma protein, E2F1, and Condensin II localizes to major satellite repeats at pericentromeres. In...
ORGANISM(S): Mus musculus 
2014-06-19 | E-GEOD-51558 | biostudies-arrayexpress
GenomicsTranscription factor ChIP-seq in expanded human hematopoietic stem and progenitor cells
While many individual transcription factors are known to regulate hematopoietic differentiation, major aspects of the global architecture of hematopoiesis remain unknown. Here, we profiled gene expression in 38 distinct purified populations of human hematopoietic cells and used probabilistic models ...
ORGANISM(S): Homo sapiens 
2011-01-26 | E-GEOD-26014 | biostudies-arrayexpress
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