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TranscriptomicsExpression data from mouse cumulus cells
Follicle stimulating hormone (FSH) and epidermal growth factor (EGF) are currently used on cumulus-oocyte complexes to mimic the luteinizing hormone surge in vitro and induce oocyte maturation and cumulus expansion. We have previously shown that addition of exogenous recombinant growth differentiati...
ORGANISM(S): Mus musculus 
2011-12-10 | E-GEOD-19327 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human mesenchymal stem cells cultured on collagenase material against tissue culture plastic controls
Human adipose and bone marrow-derived mesenchymal stem cells were cultured either on collagenase biomaterial (CardioCel®) or normal tissue culture plastic over 48 hours in standard culture conditions, in serum-free medium.
ORGANISM(S): Homo sapiens 
2021-12-23 | E-MTAB-9976 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human adipose-derived mesenchymal stem cells cultured in hypoxia against normoxia controls, and human tympanic membrane keratinocytes
Human adipose-derived mesenchymal stem cells were cultured either in hypoxia (Hx; <0.1% oxygen) or standard culture conditions (normoxia, Nx) over 48 hours in serum-free medium. Human tympanic membrane keratinocytes were cultured in standard culture conditions over 48 hours in serum-free medium.
ORGANISM(S): Homo sapiens 
2022-03-31 | E-MTAB-9979 | biostudies-arrayexpress
TranscriptomicsCytokine stimulation systems approach demonstrates differences in innate and pro-inflammatory host responses between genetically distinct MERS-CoV isolates.
Background: The recent emergence of a novel coronavirus in the Middle East (designated MERS-CoV) is a reminder of the zoonotic potential of coronaviruses and the severe disease these etiologic agents can cause in humans. Clinical features of Middle East respiratory syndrome (MERS) include severe acu...
ORGANISM(S): Homo sapiens 
2014-08-31 | E-GEOD-56677 | biostudies-arrayexpress
TranscriptomicsCell host-response to infection with novel human coronavirus EMC predict potential antivirals and important differences with SARS-coronavirus.
Differential expression was determined in Calu-3 cells between mock infected and infection with either Human coronavirus EMC and SARS coronavirus at different times post infection. Calu-3 2B4 cells were infected with Human Coronavirus EMC 2012 (HCoV-EMC) or mock infected. Samples were collected 0, ...
ORGANISM(S): Homo sapiens 
2013-05-03 | E-GEOD-45042 | biostudies-arrayexpress
TranscriptomicsHost-influenza A virus(infA) interactions
This SuperSeries is composed of the following subset Series: GSE36461: MiRNA profiling during infection with H1N1 influenza A virus (A/Mexico/InDRE4487/H1N1/2009) GSE36462: MiRNA profiling during infection with H7N7 influenza A virus (A/Ck/Germany/R28/H7N7/2003) GSE36553: mRNA profiling during infec...
ORGANISM(S): Homo sapiens 
2012-04-09 | E-GEOD-36555 | biostudies-arrayexpress
TranscriptomicsSingle cell sequencing of developing heart valves identifies novel cell populations and uncovers interstitial cell heterogeneity
This study has two main goals. The first is to define a gene expression atlas of heart valve cells and identify cell heterogeneity within postnatal heart valve development. The second is to identify interstitial cell populations involved in ECM remodeling during postnatal heart valve development. Ov...
ORGANISM(S): Mus musculus 
2018-07-13 | E-HCAD-18 | biostudies-arrayexpress
TranscriptomicsMiRNA profiling during infection with H1N1 influenza A virus (A/Mexico/InDRE4487/H1N1/2009)
MicroRNAs (miRNAs) repress the expression levels of genes by binding to mRNA transcripts, acting as master regulators of cellular processes. Differential expression of miRNAs has been linked to viral-associated diseases involving members of the hepacivirus, herpesvirus, and retrovirus families. In c...
ORGANISM(S): Homo sapiens 
2012-04-09 | E-GEOD-36461 | biostudies-arrayexpress
TranscriptomicsMiRNA profiling during infection with H7N7 influenza A virus (A/Ck/Germany/R28/H7N7/2003)
MicroRNAs (miRNAs) repress the expression levels of genes by binding to mRNA transcripts, acting as master regulators of cellular processes. Differential expression of miRNAs has been linked to viral-associated diseases involving members of the hepacivirus, herpesvirus, and retrovirus families. In c...
ORGANISM(S): Homo sapiens 
2012-04-09 | E-GEOD-36462 | biostudies-arrayexpress
TranscriptomicsModeling of Aberrant Epithelial Reprogramming in Idiopathic Pulmonary Fibrosis using Human Induced Pluripotent Stem Cell-derived Alveolar Organoids
Alveolar type 2 (AT2) organoids, derived from induced pluripotent stem cells, were stimulated with a fibrosis cocktail containing the pro-fibrotic and inflammatory cytokines TGF-β (5 ng/ml), TNF-α (10 ng/ml), PDGF-AB (10 ng/ml) and LPA (5 μM) or control cocktail containing diluents for 72 h.
ORGANISM(S): Homo sapiens 
2023-05-22 | E-MTAB-11676 | biostudies-arrayexpress
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