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ProteomicsErk1R84H is an oncoprotein that causes hepatocellular carcinoma in mice and imposes rigorous negative feedback loop on the RTK-Ras-Raf-MEK pathway
The extracellular signal-regulated kinases (Erks), Erk1 and Erk2, are crucial components of the receptor tyrosine kinase (RTK)-Ras-Raf-MEK pathway, which is frequently mutated and constitutively activated in various cancers. Despite Erk activity being commonly observed in cancer, the role of direct ...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-04 | PXD056168 | Pride
Proteomics Phosphorylation Mapk Phosphoproteomics Kinase Autoactivation Erk 
ProteomicsErk1R84H is an oncoprotein that causes hepatocellular carcinoma in mice and imposes rigorous negative feedback loop on the RTK-Ras-Raf-MEK pathway- Global proteomics
The extracellular signal-regulated kinases (Erks), Erk1 and Erk2, are crucial components of the receptor tyrosine kinase (RTK)-Ras-Raf-MEK pathway, which is frequently mutated and constitutively activated in various cancers. Despite Erk activity being commonly observed in cancer, the role of direct ...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-04 | PXD058196 | Pride
Proteomics Phosphorylation Mapk Phosphoproteomics Kinase Autoactivation Erk 
UnknownPrehospital use of magnesium sulfate as neuroprotection in acute stroke.
Not available
S-EPMC4920545 | biostudies-literature
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