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MetabolomicsUniquely Tumor-Selective Englerin A Profoundly Alters Lipid Metabolism in Renal Cell Carcinoma inducing ER-Stress and an Acute Inflammatory Response
Not available
ORGANISM(S): Homo sapiens 
ST000465 | MetabolomicsWorkbench
ProteomicsEnglerin A rewires phosphosignaling via HSP27 hyperphosphorylation to induce cytotoxicity in renal cancer cells
Englerin A (EA) is a small molecule natural product with selective cytotoxicity against renal cancer cells. EA has been shown to induce apoptosis and cell death through cell cycle arrest and/or insulin signaling pathways. However, its specific biological mode of action or targets in renal cancer rem...
ORGANISM(S): Homo sapiens (Human) 
2022-07-25 | PXD034333 | Pride
Hsp27 Anti-cancer drug Phosphoproteomics Renal cancer Englerin a 
TranscriptomicsGene expression analysis of renal cell carcinoma cell line A-498 after 3-hour treatment with englerin A.
Natural products possess enormous structural and chemical diversity and are a rich source of drugs or drug-like leads. Although the final products may not necessarily represent the active ingredients of the natural source, the majority of all drugs in the market have their origin in nature. Englerin...
ORGANISM(S): Homo sapiens 
2017-02-24 | GSE86044 | GEO
TranscriptomicsGene expression analysis of renal cell carcinoma cell line A-498 after 20-hour treatment with englerin A.
Natural products possess enormous structural and chemical diversity and are a rich source of drugs or drug-like leads. Although the final products may not necessarily represent the active ingredients of the natural source, the majority of all drugs in the market have their origin in nature. Englerin...
ORGANISM(S): Homo sapiens 
2017-02-24 | GSE86046 | GEO
TranscriptomicsGene expression analysis of renal cell carcinoma cell line A-498 after 8-hour treatment with englerin A.
Natural products possess enormous structural and chemical diversity and are a rich source of drugs or drug-like leads. Although the final products may not necessarily represent the active ingredients of the natural source, the majority of all drugs in the market have their origin in nature. Englerin...
ORGANISM(S): Homo sapiens 
2017-02-24 | GSE86045 | GEO
UnknownImportance of a 4-Alkyl Substituent for Activity in the Englerin Series.
Not available
S-EPMC5512125 | biostudies-literature
UnknownBiological Effects of Modifications of the Englerin A Glycolate.
Not available
S-EPMC9465829 | biostudies-literature
UnknownEnglerin A Agonizes the TRPC4/C5 Cation Channels to Inhibit Tumor Cell Line Proliferation.
Not available
S-EPMC4476799 | biostudies-literature
UnknownBridgehead Modifications of Englerin A Reduce TRPC4 Activity and Intravenous Toxicity but not Cell Growth Inhibition.
Not available
S-EPMC7488277 | biostudies-literature
UnknownUnveiling (-)-Englerin A as a Modulator of L-Type Calcium Channels.
Not available
S-EPMC5042069 | biostudies-literature
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