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TranscriptomicsHSP27 3A vs WT
human bronchial smooth muscle cells were infected with adenoviral constructs containing either the phosphorylation mutant form of HSP27 (HSP27-3A) or the wild type form (HSP27-WT) at 40 MOI for 4 days. All sets were stimulated with a cytokine mixture containing 10 ng/ml IL-1beta, TNF-alfa, and gamm...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-1292 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of castration-resistant prostate cancer PC-3 cells treated with Hsp27-siRNA or control siRNA to study the role of Heat shock protein (Hsp) 27 in splicing
In order to investigate the involvement of Hsp27 in splicing, we performed a whole-genome exonic expression profiling of the castration-resistant prostate cancer PC-3 cells treated by Hsp27-siRNA or CTL-siRNA (both in biological duplicates).
ORGANISM(S): Homo sapiens 
2015-06-30 | E-MTAB-1786 | biostudies-arrayexpress
ProteomicsLysosomal damage triggers a p38 MAPK-dependent phosphorylation cascade to promote lysophagy via the small heat shock protein HSP27
Maintenance of lysosomal integrity is essential for cell viability. Upon injury, lysosomes may be targeted for degradation via a form of selective autophagy known as lysophagy, in which autophagosomes engulf damaged lysosomes following the recruitment of adaptor proteins. One of these adaptors, SQST...
ORGANISM(S): Homo sapiens (Human) 
2024-10-22 | PXD051927 | Pride
Sqstm1/p62 Hsp27 Lysophagy. Phosphorylation Phase-separation Condensates 
TranscriptomicsHsp27 acts as a master molecular chaperones and plays an essential role in hepatocellular carcinoma metastasis
Hsp27 can regulate multiply signaling pathway and protect HCC cells apoptosis by mediating interaction with its cochaperones 3 HepG2 samples stably transfected with Hsp27 ORF vectors, Hsp27 shRNA or control vectors
ORGANISM(S): Homo sapiens 
2012-05-21 | E-GEOD-38080 | biostudies-arrayexpress
ProteomicsHSP27 Functional Switch Drives Castration-Resistant Prostate Cancer via mTOR Pathway Activation, Highlighting Promising Combination Therapies to Restore Treatment Sensitivity
Heat shock protein 27 (HSP27) is a multifunctional protein that plays pivotal roles in prostate cancer (PC) progression to a castration-resistant state, known as CRPC. In this study, we identified and analyzed HSP27-protein interaction maps across various prostatic cell models recapitulating differe...
ORGANISM(S): Homo sapiens (Human) 
2026-07-21 | PXD056858 | Pride
Ap-ms Lc-msms Castration resistant prostate cancer (crpc) Hsp27 Mtor pathway Interactome 
TranscriptomicsExpression profiling, siRNA mediated knockdown of PPARbeta/delta and HSP27 it HeLa cells under IL1b stimulation
HeLa cells were depeleted for PPARbeta/delta or HSP27 and treated with IL1b
ORGANISM(S): Homo_sapiens 
2013-05-14 | E-MTAB-1212 | biostudies-arrayexpress
TranscriptomicsHuman pulmonary microvascular endothelial cells (HPMECs): Control siRNA vs HSP27 siRNA
Transcriptional profiling of HPMECs comparing Control siRNA treated with HSP27 siRNA Two-condition experiment, control siRNA vs HSP27 siRNA ; 3 controlsiRNA transfected replicates , 3HSP27 siRNA replicates. Replicates were pooled and hybridized to a single array.
ORGANISM(S): Homo sapiens 
2015-08-29 | E-GEOD-72485 | biostudies-arrayexpress
ProteomicsEnglerin A rewires phosphosignaling via HSP27 hyperphosphorylation to induce cytotoxicity in renal cancer cells
Englerin A (EA) is a small molecule natural product with selective cytotoxicity against renal cancer cells. EA has been shown to induce apoptosis and cell death through cell cycle arrest and/or insulin signaling pathways. However, its specific biological mode of action or targets in renal cancer rem...
ORGANISM(S): Homo sapiens (Human) 
2022-07-25 | PXD034333 | Pride
Hsp27 Anti-cancer drug Phosphoproteomics Renal cancer Englerin a 
TranscriptomicsHSP27 3A vs WT
human bronchial smooth muscle cells were infected with adenoviral constructs containing either the phosphorylation mutant form of HSP27 (HSP27-3A) or the wild type form (HSP27-WT) at 40 MOI for 4 days. All sets were stimulated with a cytokine mixture containing 10 ng/ml IL-1beta, TNF-alfa, and gamma...
ORGANISM(S): Homo sapiens 
2004-04-09 | GSE1292 | GEO
TranscriptomicsHuman pulmonary microvascular endothelial cells (HPMECs): Control siRNA vs HSP27 siRNA
Transcriptional profiling of HPMECs comparing Control siRNA treated with HSP27 siRNA
ORGANISM(S): Homo sapiens 
2015-08-29 | GSE72485 | GEO
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