Phase-separation

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Unknown (6295)
Proteomics (4784)
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Other (94)
Methylation profiling (5)
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Organisms

Homo sapiens (537)
Mus musculus (335)
Arabidopsis thaliana (37)
Rattus norvegicus (28)
Drosophila melanogaster (27)
Saccharomyces cerevisiae (26)
Caenorhabditis elegans (19)
Danio rerio (15)
Gallus gallus (14)
Escherichia coli (13)
Schizosaccharomyces pombe (10)
Escherichia coli str. K-12 substr. MG1655 (10)
Candida albicans (10)
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Azoarcus sp. (5)
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Mycobacterium tuberculosis H37Rv (4)
Oncorhynchus mykiss (3)
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Sus scrofa (2)
Microcoleus vaginatus (1)
Cucumis sativus var. sativus (1)
Streptococcus pneumoniae TIGR4 (1)

Organisms

Homo sapiens (286)
Mus musculus (143)
Arabidopsis thaliana (19)
Drosophila melanogaster (10)
Saccharomyces cerevisiae (8)
Danio rerio (6)
Caenorhabditis elegans (5)
Xenopus tropicalis (3)
Candida albicans (3)
Plasmodium falciparum (3)
Oryza sativa Japonica Group (3)
Escherichia coli str. K-12 substr. MG1655 (2)
Xenopus laevis (2)
Schizosaccharomyces pombe (2)
Solanum lycopersicum (2)
Bombyx mori (2)
Escherichia coli (2)
Rattus norvegicus (2)
Gallus gallus (2)
Xenopus tropicalis x Xenopus laevis (1)
Eoperipatus sp. (1)
Leishmania mexicana (1)
Leishmania infantum (1)
Halobacterium salinarum NRC-1 (1)
Epiperipatus cf. barbadensis (1)
Saccharolobus islandicus (1)
Arabidopsis arenicola (1)
Cryptococcus neoformans (1)
Tetrahymena thermophila (1)
Lactobacillus delbrueckii subsp. bulgaricus (1)

Repository

pride (4559)
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geo (552)
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Tissue

Cell culture (899)
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Represent tolerant CD4+ T cells that have not been activated (1)
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Diabetes mellitus (1)
Not Available (1)

Technology Type

Mass Spectrometry (4559)
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Bottom-up proteomics (932)
Mass spectrometry (579)
Data-dependent acquisition (564)
Mass spectrometry assay (432)
Affinity purification coupled with mass spectrometry proteomics (347)
Data-independent acquisition (255)
Gel-based experiment (255)
SWATH MS (192)
Top-down proteomics (162)
Chemical cross-linking coupled with mass spectrometry proteomics (133)
HDMSE (98)
SRM/MRM (62)
All-ion fragmentation (32)
DiaPASEF (29)
MSE (23)
Immunopeptidomics (14)
NMR spectroscopy (13)
Affinity proteomics (12)
Mass spectrometry imaging (10)
Proteogenomics (8)
Metaproteomics (6)
RNA mass spectrometry (4)
Glycoproteomics (2)
NMR spectroscopy assay (1)
Two Dimensional Polyacrylamide Gel Electrophoresis (1)
PAcIFIC (1)

Instrument Platform

Illumina NovaSeq 6000 (30)
Illumina HiSeq 4000 (17)
NextSeq 500 (15)
Illumina HiSeq 2500 (7)
Illumina HiSeq 2000 (7)
ScanArray 5000 [PerkinElmer] (3)
GenePix 4000A [Axon Instruments] (3)
Illumina NovaSeq X (3)
DNBSEQ-G400 (3)
Illumina MiSeq (3)
BeadBug Benchtop homogenizer (2)
ScanArray Express HT [PerkinElmer] (2)
N/A (2)
Illumina HiSeq 1500 (2)
Agilent SureScan Microarray Scanner G2600D (1)
Thermal cycler, Agilent BioAnalyzer 2100 (1)
Microcentrifuge, vortex spinner, pipettes, -80C freezer (1)
Zeiss Stereomicroscope, standard lab plasticware (1)
DNBSEQ Devices (1)
TriFast (VWR, 30-2010), RNeasy Mini Kit (Qiagen, 74104), DNAse 1 (NEB, M0303); Agilent 2100 Bioanalyzer (1)
HEK-293T cells, Media, PEI, Illumination device (1)
MGISEQ-2000RS (1)
Linux server, HPC cluster (1)
Not applicable in this study (1)
Thermal cycler (Bio-Rad C1000), Agilent 2100 Bioanalyzer, Qubit 4 Fluorometer (1)
Benchtop centrifuge, vortex, NanoDrop or plate reader (for RiboGreen assay), TapeStation (Agilent) (1)
Liquid nitrogen freezer, surgical instruments (1)
Microarray scanner system (1)
Infors HT Multitron shaker (1)
HiSeq X Five (1)

Publication Date

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2020 (376)
2019 (318)
2018 (276)
2017 (197)
2016 (193)
2015 (108)
2014 (100)
2013 (68)
2012 (63)
2010 (52)
2011 (43)
2009 (29)
2005 (26)
2008 (25)
2007 (14)
2004 (14)
2006 (12)
2027 (3)
2003 (1)

UNIPROT ID/AC

F1LYZ3_RAT (1)
PR5A1_RAT (1)
F1M4Q9_RAT (1)
10116.ENSRNOP00000047126 (1)
A4FTZ7_RAT (1)
F1M023_RAT (1)
MEFV_RAT (1)
10116.ENSRNOP00000019177 (1)
TLR4_RAT (1)
D4A3R3_RAT (1)
M0RBJ4_RAT (1)
10116.ENSRNOP00000067569 (1)
S19A1_RAT (1)
Q7TQN6_RAT (1)
10116.ENSRNOP00000059911 (1)
PDGFA_RAT (1)
10116.ENSRNOP00000065783 (1)
M0RAK1_RAT (1)
O35531_RAT (1)
M0R7W8_RAT (1)
D3ZK92_RAT (1)
10116.ENSRNOP00000020846 (1)
10116.ENSRNOP00000061375 (1)
NTR1_RAT (1)
S10A3_RAT (1)
F1LXQ0_RAT (1)
D3ZQ01_RAT (1)
10116.ENSRNOP00000062893 (1)
F1LPU0_RAT (1)
10116.ENSRNOP00000048585 (1)

CHEBI ID

CHEBI:17368 (128)
CHEBI:16335 (114)
CHEBI:30769 (112)
CHEBI:17596 (109)
CHEBI:16704 (107)
CHEBI:16708 (100)
CHEBI:15741 (99)
CHEBI:15891 (99)
CHEBI:28044 (97)
CHEBI:16737 (94)
CHEBI:16919 (93)
CHEBI:27897 (93)
CHEBI:7916 (92)
CHEBI:17568 (91)
CHEBI:17750 (91)
CHEBI:17295 (91)
CHEBI:15354 (90)
CHEBI:16750 (89)
CHEBI:16015 (89)
CHEBI:15428 (88)
CHEBI:17895 (88)
CHEBI:17154 (87)
CHEBI:17015 (86)
CHEBI:18186 (85)
CHEBI:29016 (84)
CHEBI:16027 (84)
CHEBI:30915 (83)
CHEBI:16828 (82)
CHEBI:26271 (81)
CHEBI:28300 (81)

Metabolite Name

Hypoxanthine (180)
Adenosine (158)
Creatine (153)
Taurine (152)
Adenine (151)
Uridine (150)
Creatinine (140)
Guanosine (138)
Inosine (136)
Cytidine (132)
Uracil (127)
L-Tyrosine (125)
Xanthine (123)
Betaine (121)
Choline (120)
L-Phenylalanine (119)
L-Histidine (118)
Cytosine (118)
L-Tryptophan (118)
Guanine (114)
Azelaic acid (108)
Xanthosine (107)
Riboflavin (107)
L-Glutamine (106)
Oleamide (103)
Thymine (101)
Citric acid (98)
Uric acid (97)
L-Arginine (96)
L-Proline (95)

First Public Date

2025 (155)
2024 (125)
2026 (92)
2023 (80)
2021 (69)
2022 (40)
2020 (30)
2019 (27)
2014 (16)
2018 (12)
2015 (5)
2013 (3)
2017 (2)

Classification

bacteria (6)
protozoa (5)
fungi (4)
viruses (1)

Modification

4x(15)N labeled L-arginine (11)
2x(15)N labeled L-lysine (9)
4-tetrahydrothiazine-3-carboxylic acid (8)
57.021464 (5)
-18.010565 (4)
-17.026549 (4)
42.010565 (4)
15.994915 (4)
N6 (4)
57.02146 (3)
15.99491 (3)
+3amu) (3)
Heavy form - site K (2)
79.966331 (2)
N6-dimethyl-L-lysine (2)
Not available (2)
Light form - site K (1)
Heavy form (1)
Medium form - site K (1)
Medium form - site N-term (1)
6-dioxaoctanediamine derivatized cysteine (1)
58.005479 (1)
203.0794 (1)
0.984 (1)
42.01056 (1)
79.96633 (1)
4 (1)

Study status

Not yet recruiting (1)

Study type

Transcription profiling by array (334)
RNA-seq of coding RNA (82)
ChIP-seq (12)
Comparative genomic hybridization by array (10)
Other (10)
RNA-seq of non coding RNA (10)
ChIP-chip by tiling array (8)
RNA-seq of total RNA (8)
Unknown experiment type (5)
Animal - High-throughput sequencing (5)
MicroRNA profiling by high throughput sequencing (4)
MicroRNA profiling by array (4)
Methylation profiling by array (3)
RNA-seq of coding RNA from single cells (3)
High-throughput sequencing (2)
Transcription profiling by tiling array (2)
ChIP-chip by array (2)
Methylation profiling by high throughput sequencing (2)
Human - High-throughput sequencing (1)
Human - One-color microarray (1)
Cell line - High-throughput sequencing (1)
Proteomic profiling by mass spectrometer (1)
RNAi profiling by array (1)
Genotyping by array (1)
Transcription profiling by RT-PCR (1)
Bisulfite-seq (1)
ATAC-seq (1)
Ribo-seq (1)
CUT&RUN (1)
Observational (1)

Release Date

2025 (937)
2023 (879)
2022 (826)
2024 (756)
2021 (660)
2020 (507)
2019 (400)
2018 (352)
2017 (213)
2016 (211)
2026 (171)
2015 (152)
2013 (123)
2014 (121)
2012 (103)
2011 (92)
2010 (88)
2009 (55)
2008 (50)
2007 (32)
2005 (27)
2006 (23)
2004 (16)
2002 (6)
2003 (5)
2000 (3)
1998 (2)
1997 (2)
2001 (1)
1996 (1)

Lab affiliation

University of Vienna, Faculty of Chemistry, Department of Analytical Chemistry (120)
Proteomics Core Facility and Research Group Proteomics, CEITEC-MU, Masaryk University, Brno, Czech Republic (67)
Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, United States (36)
iBET – Instituto de Biologia Experimental e Tecnológica, Av. da República, Oeiras, 2780-157, Portugal (14)
Max Planck Institute for Terrestrial Microbiology Karl-von-Frisch Str. 10 35043 Marburg Germany (14)
Functional Proteomics, ICR (14)
Department of Biochemistry and Functional Proteomics, Institute of Biology II, Faculty of Biology and BIOSS Centre for Biological Signalling Studies, University of Freiburg, 79104 Freiburg im Breisgau, Germany (11)
DZNE Munich, Neuroproteomics, Feodor-Lynen Str. 17, 81377 Munich, Germany (10)
University of Oxford (9)
Utrecht University (9)
Chair of Biochemistry II, Theodor Boveri-Institute, Biocenter, University of Würzburg, Würzburg, Germany (8)
Masaryk University, Faculty of Science (8)
University of Victoria (8)
The Institute of Cancer Research (8)
Department of Biotechnology, Delft University of Technology, The Netherlands. (7)
Moffitt Cancer Center Tampa, FL, USA (7)
ETH Zurich (7)
Proteomics Core Facility, Biozentrum, University of Basel, Switzerland (7)
Ludwig-Maximilians-Universität München Genzentrum Laboratory for Functional Genome Analysis Feodor-Lynen-Str. 25 D-81377 München (7)
Division of Cell Matrix Biology & Regenerative Medicine (L5) / Division of Cell Matrix Biology & Regenerative Medicine, University of Manchester (6)
INEPCP FRCCP RAS, Moscow, Russia (6)
Centre for Applied Pharmacokinetic Research, School of Health Sciences, The University of Manchester, UK (6)
University of Vienna (6)
Cellzome (6)
Center for Reproductive Evolution, Biology Department, Syracuse University (6)
Institute of Cancer Research, London (6)
Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe University Frankfurt am Main, Germany (6)
ProGenTomics, Laboratory of Pharmaceutical Biotechnology, Ghent University, B-9000 Ghent, Belgium (6)
Systematic Proteome Research & Bioanalytics, Institute for Experimental Medicine, Christian-Albrechts-Universität zu Kiel, Kiel, Germany (6)
Basic Immune System of Plants / Protein Mass Spectrometry Max Planck Institute for Plant Breeding Research Carl-von-Linne-Weg 10, 50829 Cologne, Germany (6)

Keyword

Radiation-induced late intestinal injury, Rectal cancer, NCRT, TME, Phase separation (1)

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RIOK1 Phase Separation Shapes Stress Adaptation and Cell Fate in Hepatocellular Carcinoma

Cancer cells can always be unexpected rescued from desperate environment by mounting adaptive responses to resolve the arising cellular stress. The dynamic stress granules (SGs) assembly and metabolic reprogramming play crucial roles in maintaining cellular growth and homeostasis. However, the me...

2025-02-26 | MTBLS11963 | MetaboLights

LEM2 phase separation promotes ESCRT-mediated nuclear envelope reformation

Quantitative crosslinking analysis to probe in vitro conformational dynamics governing ESCRT-mediated nuclear envelope formation. CHMP7 was crosslinked with D12-BS3 while CHMP7 in the presence of LEM2 winged helix domain was crosslinked with H12-BS3. Samples were mixed after crosslinking and analy...

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

2020-01-24 | MSV000084837 | MassIVE

Enhanced Phase Separation Mediated Oncogenicity [HiC]

PRJNA1003850 | ENA

The phase separation-dependent FUS interactome reveals nuclear and cytoplasmic function of liquid-liquid phase separation

Liquid-liquid phase separation (LLPS) of proteins and RNAs has emerged as the driving force underlying the formation of membrane-less organelles. Such biomolecular condensates have various biological functions and have been linked to disease. One of the best studied proteins undergoing LLPS is Fused...

ORGANISM(S): Homo sapiens (Human)

2021-09-08 | PXD015834 | Pride