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MetabolomicsIntegrated GWAS and metabolomic analyses identified metabolic pathways and candidate genes involved in free asparagine accumulation in durum wheat grain

Free asparagine content is a key factor in acrylamide formation in wheat derivatives after high temperature processing. Therefore, the control of free asparagine levels is of interest in crop and food sciences. Our study aims to explore the natural variation in durum wheat to identify candidate g...

2025-05-23 | MTBLS10381 | MetaboLights
ProteomicsSirtuin 5 Reduces Malonylation in Non-mitochondrial Metabolic Pathways in Diabetic Kidney Disease
Early diabetic kidney disease (DKD) is marked by dramatic metabolic reprogramming due to nutrient excess, mitochondrial dysfunction, and increased renal energy requirements from hyperfiltration. We hypothesized that changes in metabolism in DKD may be regulated by Sirtuin 5 (SIRT5), a deacylase that...
ORGANISM(S): Mus Musculus 
PXD037819 | panorama
MetabolomicsMetabolome analysis reveal key regulatory pathways of feed conversion efficiency of oriental river prawn Macrobrachium nipponense

A total of 445 and 247 differently expressed metabolites (DEMs) were identified in the hepatopancreas and muscle. In addition, 11 KEGG pathways, which mainly include lysine biosynthesis, lysine degradation, aminoacyl-tRNA biosynthesis and purine metabolism, were sign...

2023-02-28 | MTBLS6663 | MetaboLights
MetabolomicsIntegration of metabolomics and transcriptomics reveals major metabolic pathways and potential biomarkers involved in pulmonary tuberculosis and pulmonary tuberculosis-complicated diabetes

Pulmonary tuberculosis (PTB) and diabetes mellitus (DM) are common chronic diseases that threaten human health. Patients with DM are susceptible to PTB, an important factor that aggravates the complications of diabetes. However, the molecular regulatory mechanism underlying the susceptibility of ...

2023-07-26 | MTBLS7623 | MetaboLights
MetabolomicsA gut-associated Prevotellaceae_NK3B31_group lineage modulates host metabolic pathways and enhances feed efficiency in ducks

Amidst the mismatch between domestic feed supply and demand in China, along with the competition for food between humans and animals, optimizing feed efficiency has become crucial for industry growth. Nevertheless, the biological processes driving variations in feed efficiency remain unexplored. ...

2026-03-10 | MTBLS14013 | MetaboLights
MetabolomicsA gut-associated Prevotellaceae_NK3B31_group lineage modulates host metabolic pathways and enhances feed efficiency in ducks

Amidst the mismatch between domestic feed supply and demand in China, along with the competition for food between humans and animals, optimizing feed efficiency has become crucial for industry growth. Nevertheless, the biological processes driving variations in feed efficiency remain unexplored. ...

2026-03-10 | MTBLS14017 | MetaboLights
MetabolomicsA gut-associated Prevotellaceae_NK3B31_group lineage modulates host metabolic pathways and enhances feed efficiency in ducks

Amidst the mismatch between domestic feed supply and demand in China, along with the competition for food between humans and animals, optimizing feed efficiency has become crucial for industry growth. Nevertheless, the biological processes driving variations in feed efficiency remain unexplored. ...

2026-03-10 | MTBLS14009 | MetaboLights
MetabolomicsL-Citrulline and L-arginine regulate the reproductive performance of young and adult cows through distinct metabolic pathways and the shared pyrimidine metabolic pathway respectively

(Background)To investigate the impact of L-arginine (L-Arg) and L-citrulline (L-Cit) on cow reproductive performance.(Methods) 90 healthy, age-matched Simmental cows were randomly assigned to three groups: control, L-Arg, and L-Cit, with 30 cows per group. Estrus synchronization was performed, an...

2025-07-05 | MTBLS12682 | MetaboLights
MetabolomicsMongolian medicine Wulanwendusu-11 ameliorates myocardial ischemia-reperfusion injury in association with the modulation of intestinal microbiota and associated metabolic pathways

Abstract

Objective: Wulanwendusu-11 (WLWDS-11), a traditional Mongolian medicinal formula, is commonly used for the treatment of Cardiovascular diseases. However, its therapeutic material basis and in vivo metabolic profile in the context of chronic myocardial ischemia-reperfusion injury (M...

2025-11-22 | MTBLS13370 | MetaboLights
TranscriptomicsGlomerular Transcriptome from European Renal cDNA Bank subjects and living donors
Glomerular Transcriptome from European Renal cDNA Bank subjects and living donors. Samples included in this analysis have been previously analyzed using older CDF definitions and are included under previous GEO submissions - GSE47183 (chronic kidney disease samples), and GSE32591 (IgA nephropathy sa...
ORGANISM(S): Homo sapiens 
2018-01-24 | E-GEOD-104948 | biostudies-arrayexpress
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