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GenomicsDynamic analysis of gene expression and genome wide transcription factor binding during lineage-specification of multipotent progenitors [ChIP-seq].
We used the paradigmatic 'GATA-PU.1 axis’ to explore, at systems-level, dynamic relationships between transcription factor (TF) binding and global gene expression programs as multipotent cells differentiate. We combined global ChIPSeq of GATA1, GATA2 and PU.1 with expression profiling during differe...
ORGANISM(S): Mus musculus 
2013-10-17 | E-GEOD-50406 | biostudies-arrayexpress
TranscriptomicsDynamic analysis of gene expression and genome wide transcription factor binding during lineage-specification of multipotent progenitors [PC]
Primary hematopoietic cells from mouse bone marrow were sorted and hybridised expression microarrays as part of a study investigating the differentiation of a multipotential cell-line to erthroid and myeloid fates. We used the paradigmatic 'GATA-PU.1 axis’ to explore, at systems-level, dynamic relat...
ORGANISM(S): Mus musculus 
2013-10-17 | E-GEOD-49988 | biostudies-arrayexpress
TranscriptomicsDynamic analysis of gene expression and genome wide transcription factor binding during lineage-specification of multipotent progenitors [HP]
FDCPmix cells were infected with Gata, Pu1 shRNAs and microarrayed 5 days after infecton as part of a study investigating the differentiation of a multipotential cell-line to erthroid and myeloid fates. We used the paradigmatic 'GATA-PU.1 axis’ to explore, at systems-level, dynamic relationships bet...
ORGANISM(S): Mus musculus 
2013-10-17 | E-GEOD-49989 | biostudies-arrayexpress
TranscriptomicsDynamic analysis of gene expression and genome wide transcription factor binding during lineage-specification of multipotent progenitors [TC]
An expression time course experiment to investigate gene expression changes during differentiation of multipotential cells over two lineages using the model cell line FDCPmix differentiating towards erytroid and myeloid fates. We used the paradigmatic 'GATA-PU.1 axis’ to explore, at systems-level, d...
ORGANISM(S): Mus musculus 
2013-10-17 | E-GEOD-49987 | biostudies-arrayexpress
TranscriptomicsDynamic analysis of gene expression and genome wide transcription factor binding during lineage-specification of multipotent progenitors [ER]
FDCPmix cells were infected with Gata1 and Pu1 ER fusion proteins and microarrayed after induction to reveal genes regulated by each factor as part of a study investigating the differentiation of a multipotential cell-line to erthroid and myeloid fates. We used the paradigmatic 'GATA-PU.1 axis’ to e...
ORGANISM(S): Mus musculus 
2013-10-17 | E-GEOD-49990 | biostudies-arrayexpress
GenomicsDynamic analysis of gene expression and genome wide transcription factor binding during lineage-specification of multipotent progenitors
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-10-15 | E-GEOD-49991 | biostudies-arrayexpress
UnknownTranscription factor-mediated lineage switching reveals plasticity in primary committed progenitor cells.
Not available
S-EPMC126114 | biostudies-literature
TranscriptomicsInferring rules of lineage commitment in haematopoiesis
Fractionation of EML cells isolated based on surface expression of immunophenotypic markers reveals the existence of a subpopulation that has undergone spontaneous commitment to an erythroid fate. Uncommitted fractions were compared to committed cells, derived from both spontaneous (EryCP) and cytok...
ORGANISM(S): Mus musculus 
2012-02-14 | E-GEOD-34605 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human hematopoietic stem cells, pro-B cells and TEL-AML1 tranduced cord blood cells to study TEL-AML1 associated childhood leukemia
The microarray data presented here relate to a study on TEL-AML1 associated childhood leukemia (Hong et al, 2008) the abstract of which is as follows:

"Understanding cancer pathogenesis requires knowledge of not only the specific contributory genetic mutations but also the cellular framew...
ORGANISM(S): Homo sapiens 
2008-01-20 | E-MEXP-1403 | biostudies-arrayexpress
TranscriptomicsRNA-seq as a global measure of the similarity between human pluripotent stem cell and fetal liver derived B cell hierarchies
Evidence suggests childhood acute lymphoblastic leukemia (cALL) arises in early human development. Existing models of pre-leukemic initiation using the ETV6-RUNX1 fusion do not recapitulate human disease, highlighting the need for a developmentally relevant human model system. A human pluripotent st...
ORGANISM(S): Homo sapiens 
2018-02-08 | E-MTAB-6382 | biostudies-arrayexpress
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