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GenomicsDynamic analysis of gene expression and genome wide transcription factor binding during lineage-specification of multipotent progenitors [ChIP-seq].
We used the paradigmatic 'GATA-PU.1 axis’ to explore, at systems-level, dynamic relationships between transcription factor (TF) binding and global gene expression programs as multipotent cells differentiate. We combined global ChIPSeq of GATA1, GATA2 and PU.1 with expression profiling during differe...
ORGANISM(S): Mus musculus 
2013-10-17 | E-GEOD-50406 | biostudies-arrayexpress
TranscriptomicsDynamic analysis of gene expression and genome wide transcription factor binding during lineage-specification of multipotent progenitors [PC]
Primary hematopoietic cells from mouse bone marrow were sorted and hybridised expression microarrays as part of a study investigating the differentiation of a multipotential cell-line to erthroid and myeloid fates. We used the paradigmatic 'GATA-PU.1 axis’ to explore, at systems-level, dynamic relat...
ORGANISM(S): Mus musculus 
2013-10-17 | E-GEOD-49988 | biostudies-arrayexpress
TranscriptomicsDynamic analysis of gene expression and genome wide transcription factor binding during lineage-specification of multipotent progenitors [HP]
FDCPmix cells were infected with Gata, Pu1 shRNAs and microarrayed 5 days after infecton as part of a study investigating the differentiation of a multipotential cell-line to erthroid and myeloid fates. We used the paradigmatic 'GATA-PU.1 axis’ to explore, at systems-level, dynamic relationships bet...
ORGANISM(S): Mus musculus 
2013-10-17 | E-GEOD-49989 | biostudies-arrayexpress
TranscriptomicsDynamic analysis of gene expression and genome wide transcription factor binding during lineage-specification of multipotent progenitors [TC]
An expression time course experiment to investigate gene expression changes during differentiation of multipotential cells over two lineages using the model cell line FDCPmix differentiating towards erytroid and myeloid fates. We used the paradigmatic 'GATA-PU.1 axis’ to explore, at systems-level, d...
ORGANISM(S): Mus musculus 
2013-10-17 | E-GEOD-49987 | biostudies-arrayexpress
TranscriptomicsDynamic analysis of gene expression and genome wide transcription factor binding during lineage-specification of multipotent progenitors [ER]
FDCPmix cells were infected with Gata1 and Pu1 ER fusion proteins and microarrayed after induction to reveal genes regulated by each factor as part of a study investigating the differentiation of a multipotential cell-line to erthroid and myeloid fates. We used the paradigmatic 'GATA-PU.1 axis’ to e...
ORGANISM(S): Mus musculus 
2013-10-17 | E-GEOD-49990 | biostudies-arrayexpress
GenomicsDynamic analysis of gene expression and genome wide transcription factor binding during lineage-specification of multipotent progenitors
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-10-15 | E-GEOD-49991 | biostudies-arrayexpress
UnknownTranscription factor-mediated lineage switching reveals plasticity in primary committed progenitor cells.
Not available
S-EPMC126114 | biostudies-literature
TranscriptomicsTranscription profiling of human CD133-positive G0 and G1 human ubmbilical vein cells
To identify regulators of human HSC fate, we transcriptionally profiled quiescent primitive cord blood (CB) CD133+ G0 cells enriched for long term culture initiating cell (LTC-IC) activity. CD133+ G0 cells were sorted by cell cycle status using combined DNA and RNA staining; less immature CD133+G1 c...
ORGANISM(S): Homo sapiens 
2008-03-06 | E-MEXP-1412 | biostudies-arrayexpress
TranscriptomicsInferring rules of lineage commitment in haematopoiesis
Fractionation of EML cells isolated based on surface expression of immunophenotypic markers reveals the existence of a subpopulation that has undergone spontaneous commitment to an erythroid fate. Uncommitted fractions were compared to committed cells, derived from both spontaneous (EryCP) and cytok...
ORGANISM(S): Mus musculus 
2012-02-14 | E-GEOD-34605 | biostudies-arrayexpress
GenomicsChIP-seq for RUNX1 and ETV6-RUNX1 in an induced pluripotent stem cell model of ETV6-RUNX1 pre-leukaemia
ETV6-RUNX1 is a first-hit mutation in childhood B cell precursor acute lymphoblastic leukaemia. ETV6-RUNX1 is a fusion protein which inherits the DNA-binding runt domain from RUNX1. Here we performed chromatin precipitation for native RUNX1 and ETV6-RUNX1 using RUNX1 antibodies and specifically for ...
ORGANISM(S): Homo sapiens 
2022-10-31 | E-MTAB-12208 | biostudies-arrayexpress
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