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ProteomicsProteasome-dependent truncation of the negative heterochromatin regulator Epe1 mediates antifungal resistance.
Epe1 histone demethylase restricts H3K9-methylation-dependent heterochromatin, preventing it from spreading over, and silencing, gene-containing regions in fission yeast. External stress induces an adaptive response allowing heterochromatin island formation that confers resistance on surviving wild-...
ORGANISM(S): Schizosaccharomyces pombe 927 
2022-10-13 | PXD030205 | Pride
Fission yeast Epe1 Shotgun proteomics. Anti-fungal resistance H3k9-methylation Proteasome Heterochromatin 
GenomicsThe cAMP signaling pathway regulates Epe1 protein levels and heterochromatin assembly
The cAMP signaling pathway regulates Epe1 protein levels and heterochromatin assembly
PRJNA751238 | ENA
GenomicsProteasome-dependent truncation of the negative heterochromatin regulator Epe1 mediates antifungal resistance
Proteasome-dependent truncation of the negative heterochromatin regulator Epe1 mediates antifungal resistance
PRJNA786560 | ENA
GenomicsRegulation of ectopic heterochromatin-mediated epigenetic diversification by the JmjC family protein Epe1.
Regulation of ectopic heterochromatin-mediated epigenetic diversification by the JmjC family protein Epe1.
PRJNA427305 | ENA
TranscriptomicsEpe1 recruits the BET family bromodomain protein Bdf2 to establish heterochromatin boundaries
Heterochromatin spreading leads to the silencing of genes within its path, and boundary elements have evolved to constrain such spreading. In fission yeast, heterochromatin at centromeres I and III is flanked by inverted repeats termed IRCs, which are required for proper boundary functions. However,...
ORGANISM(S): Schizosaccharomyces pombe 
2013-09-24 | E-GEOD-46430 | biostudies-arrayexpress
UnknownThe cAMP signaling pathway regulates Epe1 protein levels and heterochromatin assembly.
Not available
S-EPMC8887748 | biostudies-literature
GenomicsThe cAMP signaling pathway regulates Epe1 protein levels and heterochromatin assembly
The epigenetic landscape of a cell frequently changes in response to fluctuations in nutrient levels, but the mechanistic link is not well understood. In fission yeast, the JmjC domain protein Epe1 is critical for maintaining the heterochromatin landscape. Loss of Epe1 results in heterochromatin exp...
ORGANISM(S): Schizosaccharomyces pombe 
2022-01-10 | GSE181263 | GEO
UnknownThe JmjC domain protein Epe1 prevents unregulated assembly and disassembly of heterochromatin.
Not available
S-EPMC2048757 | biostudies-literature
UnknownProteasome-dependent truncation of the negative heterochromatin regulator Epe1 mediates antifungal resistance.
Not available
S-EPMC7613290 | biostudies-literature
UnknownAnti-silencing factor Epe1 associates with SAGA to regulate transcription within heterochromatin.
Not available
S-EPMC6317313 | biostudies-literature
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