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TranscriptomicsIdentification of immediate early transcriptional targets of ephrin-B1 forward signaling
The goal of this study was to identify immediate early transcriptional targets of ephrin-B1 forward signaling that are relevant to palatogenesis. The Ephs compose a family of receptor tyrosine kinase signaling molecules that can be activated by their cognate ligands, the ephrins. Despite the import...
ORGANISM(S): Mus musculus 
2010-09-20 | E-GEOD-23539 | biostudies-arrayexpress
ProteomicsCell-specific information processing in segregating populations of Eph receptor-ephrin-expressing cells
Cell-specific information processing in segregating populations of Eph receptor-ephrin-expressing cells
ORGANISM(S): Homo sapiens (Human) 
2009-12-11 | PRD000814 | Pride
ProteomicsSingle methyl group positioning opens new chemical space for EPH receptor kinase inhibition
EPHrin receptors (EPH) are transmembrane receptor tyrosine kinases. Their extracellular domains bind specifically to ephrin A/B ligands, and this binding modulates the intracellular kinase activity. EPHs are key players in bidirectional intercellular signalling, controlling cell morphology, adhesion...
ORGANISM(S): Homo sapiens (Human) 
2018-09-05 | PXD009188 | Pride
Eph receptor Selectivity profiling Kinase inhibitor Kinobeads 
UnknownArchitecture of Eph receptor clusters.
Not available
S-EPMC2890748 | biostudies-literature
TranscriptomicsAnalysis of the gene expression profile in cutaneous squamous cell carcinoma cells after EphB2 knockdown
The role of Eph/ephrin signaling in numerous biological processes has been established. However, Eph/ephrin signaling has been shown to have complex role in tumor progression. The role of EphB2 receptor in the progression of cutaneous squamous cell carcinoma (cSCC) has not been studied before. EphB2...
ORGANISM(S): Homo sapiens 
2015-08-27 | E-GEOD-66361 | biostudies-arrayexpress
TranscriptomicsExpression microarray screen for genes regulated by the unliganded glucocorticoid receptor
To further characterize the role of the unliganded glucocorticoid receptor (GR) in breast cells, we used an shRNA vector directed against GR to create EPH-4 mouse mammary cell lines with depleted endogenous levels of this receptor. RNA prepared from normal (EV-50) and GR-depleted (shGR-19) cells was...
ORGANISM(S): Mus musculus 
2014-05-11 | E-GEOD-51408 | biostudies-arrayexpress
UnknownEph Receptors Activate Myeloid Checkpoint Receptor LILRB5 to Support Tumor Development.
Not available
S-EPMC12137008 | biostudies-literature
UnknownStructural plasticity of eph receptor A4 facilitates cross-class ephrin signaling.
Not available
S-EPMC2832735 | biostudies-literature
ProteomicsNovel Eph receptor tyrosine kinase inhibitors block colorectal cancer cell growth
Despite advances, treatment of unresectable colorectal cancer remains a clinical challenge and the incidence of this malignancy is increasing in individuals below the age of fifty. Integrated genomic, transcriptomic, proteomic, and mechanistic studies identified the tyrosine kinase receptors EphB2 a...
ORGANISM(S): Homo sapiens (Human) 
2024-05-23 | PXD031880 | Pride
Affinity pulldowns Kinobeads Lc-ms/ms 
UnknownSpecific Eph receptor-cytoplasmic effector signaling mediated by SAM-SAM domain interactions.
Not available
S-EPMC5993539 | biostudies-literature
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