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TranscriptomicsBroad defects in epidermal cornification in atopic dermatitis (AD) identified through genomic analysis
In this study we used genomic profiling to characterize differences in expression of genes related to epidermal growth/differentiation and inflammatory circuits in skin lesions of psoriasis and atopic dermatitis (AD), comparing expression values to normal skin. Skin biopsies were collected from 9 pa...
ORGANISM(S): Homo sapiens 
2009-10-31 | E-GEOD-16161 | biostudies-arrayexpress
GenomicsTroy/Tnfrsf19 marks epidermal cells that govern interfollicular epidermal renewal and cornification
Troy/Tnfrsf19 marks epidermal cells that govern interfollicular epidermal renewal and cornification
PRJNA694196 | ENA
no omics definedTranscription profiling of human keratinocytes treated with JNK inhibitor vs. control reveals inhibition of JNK in keratinocyte cultures in vitro induces virtually all aspects of epidermal differentiation in vivo
In inflamed tissue, normal signal transduction pathways are altered by extracellular signals. For example, the JNK pathway is activated in psoriatic skin, which makes it an attractive target for treatment. To define comprehensively the JNK-regulated genes in human epidermal keratinocytes, we compare...
ORGANISM(S): Homo sapiens 
2007-10-26 | E-GEOD-4828 | biostudies-arrayexpress
TranscriptomicsAnalysis of temporal mRNA expression changes in cultured keratinocytes from Casp-8F/M-bM-^@M-^SK5-Cre and Casp-8F/+K5-Cre mice
Expression of enzymatically inactive caspase-8, or deletion of caspase-8 from basal epidermal keratinocytes, triggers chronic skin inflammation in mice. Unlike similar inflammation resulting from arrest of NF-kB activation in the epidermal cells, the effect induced by caspase-8 deficiency did not de...
ORGANISM(S): Mus musculus 
2009-07-29 | E-GEOD-17345 | biostudies-arrayexpress
UnknownTroy/Tnfrsf19 marks epidermal cells that govern interfollicular epidermal renewal and cornification.
Not available
S-EPMC8452520 | biostudies-literature
UnknownEpidermal cornification is preceded by the expression of a keratinocyte-specific set of pyroptosis-related genes.
Not available
S-EPMC5727156 | biostudies-literature
UnknownhiPSC-Derived Epidermal Keratinocytes from Ichthyosis Patients Show Altered Expression of Cornification Markers.
Not available
S-EPMC7916893 | biostudies-literature
UnknownTransient elevation of cytoplasmic calcium ion concentration at a single cell level precedes morphological changes of epidermal keratinocytes during cornification.
Not available
S-EPMC5919969 | biostudies-literature
TranscriptomicsAnalysis of spatial mRNA expression differences in the skin of Casp-8F/–K5-Cre or Casp-8F/+K5-Cre mice
Expression of enzymatically inactive caspase-8, or deletion of caspase-8 from basal epidermal keratinocytes, triggers chronic skin inflammation in mice. Unlike similar inflammation resulting from arrest of NF-kB activation in the epidermal cells, the effect induced by caspase-8 deficiency did not de...
ORGANISM(S): Mus musculus 
2009-07-29 | E-GEOD-17344 | biostudies-arrayexpress
TranscriptomicsTroy/Tnfrsf19 marks epidermal cells that govern interfollicular epidermal renewal and cornification
The skin epidermis is a highly compartmentalised tissue consisting of a cornifying epithelium called the interfollicular epidermis (IFE) and associated hair follicles (HFs). Several stem cell populations have been described that mark specific sub compartments in the skin but none of them is IFE-spec...
ORGANISM(S): Mus musculus 
2021-08-05 | GSE165379 | GEO
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