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MetabolomicsMetabolic memory underlying minimal residual disease in breast cancer

Tumor relapse from treatment-resistant cells (minimal residual disease, MRD) underlies most breast cancer related deaths. Yet, the molecular characteristics defining their malignancy have largely remained elusive. Here we integrated multi-omics data from a tractable organoid system with a metabol...

2021-09-14 | MTBLS1507 | MetaboLights
GenomicsAn epigenetic memory of pregnancy in the mouse mammary gland
Pregnancy is the major modulator of mammary gland activity. It induces a tremendous expansion of the mammary epithelium and the generation of alveolar structures for milk production. Anecdotal evidence from multiparous humans indicates that the mammary gland may react less strongly to the first preg...
ORGANISM(S): Mus musculus 
2015-05-15 | E-GEOD-67386 | biostudies-arrayexpress
TranscriptomicsEpigenetic memory mediated by HDA6, Pol IV and Pol V in Arabidopsis.
Multiple RNA-sequencing datasets were generated from wild-type Col-0 and hda6, pol IV or pol V null mutant samples to dissect genetic requirements for the maintenance of epigenetic memory and silent locus identity in Arabidopsis thaliana.
ORGANISM(S): Arabidopsis thaliana 
2014-03-27 | E-MTAB-4337 | biostudies-arrayexpress
TranscriptomicsA C. elegans LSD1 Demethylase Contributes to Germline Immortality by Reprogramming Epigenetic Memory
Microarray-based expression profiling of mixed stage populations taken from generation 1,13 and 26 spr-5 mutant animals as well as wild-type animals reveals a large class of spermatogenesis-expressed genes whose expression coordinately increased from generations 1 to 13 and then decreased from gener...
ORGANISM(S): Caenorhabditis elegans 
2010-06-19 | E-GEOD-14432 | biostudies-arrayexpress
TranscriptomicsATF7 mediates lipopolysaccharide-induced epigenetic changes in macrophages involved in innate immunological memory (expression)
Immunological memory is generally thought to be mediated exclusively by lymphocytes such as memory T and B cells. However, enhanced innate immune responses caused by a previous infection increase protection against reinfection suggesting the presence of innate immunological memory. Here, we describe...
ORGANISM(S): Mus musculus 
2015-08-31 | E-GEOD-71111 | biostudies-arrayexpress
ProteomicsAcetate enhances long-term memory in female mice by sex-, context-, and brain region–specific epigenetic and transcriptional remodeling
Metabolic control of chromatin and gene expression is emerging as a key mechanism influencing critical neuronal functions. Here, we found that the intermediary metabolite acetate enhanced long-term memory in female mice, and this was associated with epigenetic and transcriptional remodeling in the d...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-08-12 | MSV000095573 | MassIVE
TranscriptomicsEpigenetic memory of the first cell fate decision prevents complete ES cell reprogramming into trophoblast
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-11-24 | E-GEOD-62150 | biostudies-arrayexpress
TranscriptomicsATF7 mediates lipopolysaccharide-induced epigenetic changes in macrophages involved in innate immunological memory (ChIP)
Immunological memory is generally thought to be mediated exclusively by lymphocytes such as memory T and B cells. However, enhanced innate immune responses caused by a previous infection increase protection against reinfection suggesting the presence of innate immunological memory. Here, we describe...
ORGANISM(S): Mus musculus 
2015-08-31 | E-GEOD-71112 | biostudies-arrayexpress
GenomicsCRISPR screen to identify regulators of epigenetic memory in ESC
A genome-wide CRISPR screen was combined with a tdTomato reporter-based epigenetic memory assay to identify factors that erase epigenetic memory in ESC. After introducing genome wide perturbation and dCas9::KRAB-mediated epigenetic editing of the Esg1-tdTomato reporter, the trigger was released and ...
ORGANISM(S): Mus musculus 
2021-11-23 | E-MTAB-10524 | biostudies-arrayexpress
TranscriptomicspiRNAs can trigger a multigenerational epigenetic memory in the germline of C. elegans
Transgenerational effects likely have wide-ranging implications for human health, biological adaptation and evolution, however their mechanism and biology remain poorly understood. Here we demonstrate that a germline nuclear small RNA/chromatin pathway can maintain epi-allelic inheritance for many g...
ORGANISM(S): Caenorhabditis elegans 
2012-06-25 | E-GEOD-38813 | biostudies-arrayexpress
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