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MetabolomicsLactate controls cancer stemness and plasticity through epigenetic regulation.

Tumours arise from uncontrolled cell proliferation driven by mutations in genes that regulate stem cell renewal and differentiation. Intestinal tumours, however, retain some hierarchical organization, maintaining both cancer stem cells (CSCs) and cancer differentiated cells (CDCs). This heterogen...

2025-05-28 | MTBLS11849 | MetaboLights
MetabolomicsMultiomics analysis of residual feed intake regulation in calves by intestinal microbiota-mediated epigenetic modifications
Feed efficiency is a critical trait affecting the economic profitability and environmental sustainability of livestock production. Residual Feed Intake (RFI), as a key metric for feed efficiency, effectively reflects differences in energy utilization for maintenance and production. This study aims t...
2026-04-20 | MTBLS14315 | MetaboLights
MetabolomicsEpigenetic coordination of transcriptional and translational programs in hypoxia

Adaptation to cellular stresses entails an incompletely understood coordination of transcriptional and post-transcriptional gene regulation. Here, we quantified hypoxia-dependent transcriptomes, epigenomes and translatomes in T47D breast cancer cells and H9 human embryonic stem cells. This reveal...

2025-06-09 | MTBLS12086 | MetaboLights
MetabolomicsSIRT3-dependent glutaminolysis enhances germinal center epigenetic programming through α-ketoglutarate

Germinal center (GC) B cells depend on sustained epigenetic modulation to maintain transcriptional identity and support affinity maturation; however, whether mitochondrial metabolism directly enhances this chromatin state remains unclear. Here, we show that enhanced SIRT3 activity promotes glutam...

2026-09-04 | MTBLS15385 | MetaboLights
MetabolomicsComprehensive multi-omics analysis reveals the influence of epigenetic mechanisms on porcine oocyte maturation
In vitro maturation (IVM) oocyte is a key component of assisted reproduction in pigs. Asynchronous nucleoplasmic maturation and incomplete cytoplasmic maturation is one of the key factors for impaired maturation and quality of oocytes matured in vitro. Although Single-omics techniques have been appl...
2025-08-27 | MTBLS12325 | MetaboLights
MetabolomicsMicroRNA-mediated regulation of lipid metabolism in virus-infected Emiliania huxleyi.
The interactions between Emiliania huxleyi and E. huxleyi virus (EhV) regulate marine carbon and sulfur biogeochemical cycles and play a prominent role in global climate change. As a large DNA virus, EhV has developed a novel 'virocell metabolism' model to meet its high metabolic needs. Although it ...
2024-01-16 | MTBLS5178 | MetaboLights
TranscriptomicsDynamics of epigenetic regulation of gene expression during Plasmodium falciparum life cycle
In order to study the role of chromatin remodeling in transcriptional regulation associated with the progression of the P. falciparum intraerythrocytic development cycle (IDC), we mapped the temporal pattern of chromosomal association with histone H3 and H4 modifications using chromatin-immunoprecip...
ORGANISM(S): Plasmodium falciparum 
2013-03-02 | E-GEOD-39238 | biostudies-arrayexpress
MetabolomicsMulti-Omics analyses reveal dynamic interactions between DNA methylation and transcriptional regulation during black raspberry ripening
We show developmental-series transcriptome, methylome, and metabolome to reveal extensive epigenetic reprogramming during black raspberry (Rubus occidentalis) fruit ripening. Multi-omics integration reveals coordinated anthocyanin accumulation parallels expression of biosynthetic and regulatory gene...
2026-09-28 | MTBLS15819 | MetaboLights
GenomicsEpigenetic regulation and transcriptional repression by Tet1 in the early post-implantation mouse embryo: Methylation data.
The mammalian TET dioxygenases contribute to global waves of DNA demethylation in the zygote and in primordial germ cells, but their involvement during de novo DNA methylation at peri/post-implantation development is unknown. Here, we show novel physiological functions of Tet1 in the pre-primitive s...
ORGANISM(S): Mus musculus 
2017-05-15 | E-MTAB-4581 | biostudies-arrayexpress
ProteomicsEpigenetic reader ZMYND11 noncanonical function restricts HNRNPA1-mediated stress granule formation and oncogenic activity
Epigenetic reader ZMYND11 noncanonical function restricts HNRNPA1-mediated stress granule formation and oncogenic activity, PPI of ZMYND11 in LNCap
ORGANISM(S): Homo Sapiens 
2024-08-28 | PXD055421 |
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