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GenomicsEpigenetic polymorphism and the stochastic formation of differentially methylated regions in normal and cancerous tissues (ChIP-Seq and MeDIP-Seq)
DNA methylation has been comprehensively profiled in normal and cancer cells, but the dynamics that form, maintain and reprogram differentially methylated regions remain enigmatic. We show that methylation patterns within populations of cells from individual somatic tissues are heterogeneous and pol...
ORGANISM(S): Homo sapiens 
2012-09-24 | E-GEOD-41048 | biostudies-arrayexpress
GenomicsDietary induced epigenetic reprogram in mouse intestinal enterocytes
Dietary induced epigenetic reprogram in mouse intestinal enterocytes
PRJNA947654 | ENA
UnknownRepositioning FDA-Approved Drugs in Combination with Epigenetic Drugs to Reprogram Colon Cancer Epigenome.
Not available
S-EPMC5292054 | biostudies-literature
UnknownChiral Antioxidant-based Gold Nanoclusters Reprogram DNA Epigenetic Patterns.
Not available
S-EPMC5025748 | biostudies-literature
TranscriptomicsFrequent switching of Polycomb repressive marks and DNA hypermethylation in the PC3 prostate cancer cell line
Epigenetic reprogramming is commonly observed in cancer, and is hypothesized to involve multiple mechanisms, including DNA methylation and Polycomb repressive complexes (PRCs). Here we devise a new experimental and analytical strategy using customized high density tiling arrays to investigate coordi...
ORGANISM(S): Homo sapiens 
2008-08-07 | E-GEOD-12334 | biostudies-arrayexpress
GenomicsThe H3K27 demethylase Utx facilitates somatic and germ cell epigenetic reprogramming to pluripotency [ChIP-Seq]
Pluripotency can be induced in somatic cells by ectopic expression of defined transcription factors, however the identity of epigenetic regulators driving the progression of cellular reprogramming requires further investigation. Here we uncover a non-redundant role for the JmjC-domain-containing pro...
ORGANISM(S): Mus musculus 
2012-05-30 | E-GEOD-37821 | biostudies-arrayexpress
UnknownSmall Molecules Efficiently Reprogram Human Astroglial Cells into Functional Neurons.
Not available
S-EPMC4675726 | biostudies-literature
ProteomicsLife-long epigenetic programming of cortical architecture by maternal ‘ Western ’ diet during pregnancy
The evolution of human diets led to preferences towards polyunsaturated fatty acid (PUFA) content with ‘Western’ diets enriched in w-6 PUFA1. Mounting evidence points to w-6 PUFA excess limiting metabolic and cognitive processes that define longevity in humans2. When chosen during pregnancy, w-6 PUF...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-21 | PXD016180 | Pride
Fetal cortex Itraq Maternal diet Epigenetic 
TranscriptomicsTranscription profiling of mouse Dnmt3L+/- sires compared to offspring of Dnmt3L+/+ sires to investigate the effect of paternal haploinsufficiency for Dnmt3L
There is increasing evidence that epigenetic information can be inherited across generations in mammals, despite extensive reprogramming both in the gametes and the early developing embryo. One corollary to this is that disruption of the establishment of epigenetic state in the gametes of a parent, ...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7384 | biostudies-arrayexpress
GenomicsEnvironmental chemical mixtures reprogram mammary epithelial development to epigenetic states associated with breast cancer
Environmental chemical mixtures reprogram mammary epithelial development to epigenetic states associated with breast cancer
PRJNA1451208 | ENA
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