Sort   by:  
 Page size 
MetabolomicsLactate controls cancer stemness and plasticity through epigenetic regulation.

Tumours arise from uncontrolled cell proliferation driven by mutations in genes that regulate stem cell renewal and differentiation. Intestinal tumours, however, retain some hierarchical organization, maintaining both cancer stem cells (CSCs) and cancer differentiated cells (CDCs). This heterogen...

2025-05-28 | MTBLS11849 | MetaboLights
MetabolomicsThe ULK3 kinase is a key determinant of keratinocyte self-renewal and tumorigenesis targeting the arginine methylome
Epigenetic mechanisms oversee epidermal homeostasis and oncogenesis. The identification of kinases controlling these processes has direct therapeutic implications. We show that ULK3 is a nuclear kinase with elevated expression levels in squamous cell carcinomas (SCCs) arising in multiple body sites,...
2022-11-14 | MTBLS5155 | MetaboLights
ProteomicsEpigenetic Silencing by SETDB1 Suppresses Tumor-cell Intrinsic Immunogenicity
Griffin GK, Wu J, Iracheta-Vellve A, Patti JC, Hsu J, Davis T, Dele-Oni D, Du PP, Halawi A, Ishizuka JJ, Kim S, Klaeger S, Knudsen NH, Miller BC, Nguyen T, Olander K, Papanastasiou M, Rachimi S, Robitschek EJ, Schneider EM, Yeary M, Zimmer M, Jaffe JD, Carr SA, Doench JG, Haining WN, Yates KB, Mangu...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-12-11 | MSV000086580 | MassIVE
TranscriptomicsAn epigenetic role for maternally inherited piRNAs in transposon silencing
In plants and mammals, small RNAs indirectly mediate epigenetic inheritance by specifying cytosine methylation. Here, we find that small RNAs themselves serve as vectors for epigenetic information. Crosses between Drosophila strains that differ in the presence of a particular transposon can pr...
ORGANISM(S): Drosophila melanogaster 
2008-11-28 | E-GEOD-13081 | biostudies-arrayexpress
GenomicsModulation of enhancer looping and differential gene targeting by Epstein-Barr virus transcription factors directs epigenetic reprogramming
Epstein-Barr virus (EBV) epigenetically reprogrammes B-lymphocytes to drive immortalization and facilitate viral persistence. Host-cell transcription is perturbed principally through the actions of EBV EBNA 2, 3A, 3B and 3C, with cellular genes deregulated by specific combinations of these EBNAs thr...
ORGANISM(S): Homo sapiens 
2013-09-13 | E-GEOD-47629 | biostudies-arrayexpress
TranscriptomicsTargeting H3K4 methylation as a therapeutic strategy for Huntington's disease (RNA-seq)
Transcriptional dysregulation is an early feature of Huntington's disease (HD). We observed gene-specific changes in H3K4me3 at transcriptionally repressed promoters in R6/2 mouse and human HD brain. Genome-wide analysis showed a novel chromatin signature for this mark. Reducing the levels of the H3...
ORGANISM(S): Mus musculus 
2013-07-18 | E-GEOD-48962 | biostudies-arrayexpress
GenomicsTargeting H3K4 methylation as a therapeutic strategy for Huntington's disease (ChIP-seq)
Transcriptional dysregulation is an early feature of Huntington's disease (HD). We observed gene-specific changes in H3K4me3 at transcriptionally repressed promoters in R6/2 mouse and human HD brain. Genome-wide analysis showed a novel chromatin signature for this mark. Reducing the levels of the H3...
ORGANISM(S): Mus musculus 
2013-07-18 | E-GEOD-48960 | biostudies-arrayexpress
ProteomicsTargeting PURPL RNA Enabled Rejuvenation of Senescence Cells via Epigenetic Reprogramming
Cellular senescence is a fundamental driver of ageing and age-related diseases, characterized by irreversible growth arrest and profound epigenetic alterations. While long non-coding RNAs (lncRNAs) have emerged as key regulators of senescence, their potential for senescent cell rejuvenation remains ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-27 | PXD068664 | Pride
Purpl  rna binding protein  carpid 
GenomicsEpigenetic profiling of cells following KAT6A CRISPR targeting
Epigenetic profiling of cells following KAT6A CRISPR targeting
PRJNA659930 | ENA
GenomicsTargeting epigenetic networks mediated by Prmt1 and Kdm4c in acute myeloid leukemia
Targeting epigenetic networks mediated by Prmt1 and Kdm4c in acute myeloid leukemia
PRJEB8535 | ENA
Sort   by:  
 Page size