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ProteomicsTargeting PURPL RNA Enabled Rejuvenation of Senescence Cells via Epigenetic Reprogramming
Cellular senescence is a fundamental driver of ageing and age-related diseases, characterized by irreversible growth arrest and profound epigenetic alterations. While long non-coding RNAs (lncRNAs) have emerged as key regulators of senescence, their potential for senescent cell rejuvenation remains ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-27 | PXD068664 | Pride
Purpl  rna binding protein  carpid 
ProteomicsMass spectrometry (MS) datasets of PURPL RNA pulldown samples in A375 cells
We performed PURPL RNA pulldown followed by MS analysis to identify purpl-interacting proteins in A375 cells.With high performance liquid chromatography-mass spectrometry (HPLC-MS), the binding protein of PURPL from RNA pull down was detected by removing non-specific protein which were binding with ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD028863 | Pride
Human a375 cells lc-ms 
GenomicsPURPL plays a role in epigenetic regulation of gene expression [ChIP-Seq]
PURPL plays a role in epigenetic regulation of gene expression [ChIP-Seq]
PRJNA1284216 | ENA
GenomicsPURPL bidirectionally controls senescence: depletion rejuvenates fibroblasts while overexpression accelerates aging [RNA-Seq2]
PURPL bidirectionally controls senescence: depletion rejuvenates fibroblasts while overexpression accelerates aging [RNA-Seq2]
PRJNA1284215 | ENA
UnknownTargeting PURPL RNA enabled rejuvenation of senescence cells via epigenetic reprogramming.
Not available
S-EPMC12535130 | biostudies-literature
TranscriptomicsIdentification of PURPL regulated genes in HCT116 cells
Analysis of changes in gene expression profile upon depletion of PURPL in HCT116 cells. The hypothesis in this study is that PURPL regulates gene expression in the p53 pathway.
ORGANISM(S): Homo sapiens 
2017-08-03 | GSE79053 | GEO
UnknownLong Noncoding RNA PURPL Suppresses Basal p53 Levels and Promotes Tumorigenicity in Colorectal Cancer.
Not available
S-EPMC5777516 | biostudies-literature
UnknownContext-Dependent Function of Long Noncoding RNA PURPL in Transcriptome Regulation during p53 Activation.
Not available
S-EPMC9753727 | biostudies-literature
GenomicsContext-dependent function of long noncoding RNA PURPL in transcriptome regulation during p53 activation (Iso-Seq)
Context-dependent function of long noncoding RNA PURPL in transcriptome regulation during p53 activation (Iso-Seq)
PRJNA851801 | ENA
GenomicsPURPL plays a role in epigenetic regulation of gene expression [ChIP-Seq]
Cellular senescence involves heterochromatin reorganization and aberrant gene expression. We demonstrate that the nuclear-enriched lncRNA PURPL regulates senescence-associated chromatin dynamics by modulating H3K9me3 deposition. PURPL knockdown increased global H3K9me3 levels while its overexpressio...
ORGANISM(S): Homo sapiens 
2025-12-02 | GSE301169 | GEO
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