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Primate-expressed EPIREGULIN promotes basal progenitor proliferation in the developing neocortex
Epiregulin is a dendritic cell-derived EGFR ligand that maintains skin and lung fibrosis
Immune cells are fundamental regulators of extracellular matrix (ECM) production by fibroblasts and have important roles in determining extent of fibrosis in response to inflammation. Although much is known about fibroblast signaling in fibrosis, the molecular signals between immune cells and fibrob...
ORGANISM(S): Homo sapiens 
2022-12-09 | GSE214088 | GEO
Neocortex expansion during evolution is linked to higher numbers of neurons thought to result from increased proliferative capacity and neurogenic potential of basal progenitors during development. Here, we show that EREG, encoding the growth factor EPIREGULIN, is expressed in the human developing n...
ORGANISM(S): Mus musculus 
2024-02-19 | GSE228007 | GEO
Here, we used single-cell RNA-sequencing (scRNA-seq) to profile pluripotent stem cell-derived human intestinal organoids (HIOs) grown in media comprised of minigut media + varying concentrations of Epiregulin (EREG) 1 ng/ml, 10 ng/ml, 100 ng/ml after 28 days of in vitro growth.
ORGANISM(S): Homo sapiens 
scRNA-seq of pluripotent stem cell-derived human intestinal organoids grown in Epiregulin
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