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MetabolomicsThe metabolic background is a global player in Saccharomyces gene expression epistasis
The regulation of gene expression in response to nutrient availability is fundamental to the genotype-phenotype relationship. The metabolic-genetic make-up of the cell, as reflected in auxotrophy, is hence likely to be a determinant of gene expression. Here, we address the importance of the metaboli...
2016-12-16 | MTBLS168 | MetaboLights
MetabolomicsEpistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import
About a thousand genes in the human genome encode for membrane transporters. Among these, several solute carrier proteins (SLCs), representing the largest group of transporters, are still orphan and lack functional characterization. We reasoned that assessing genetic interactions among SLCs may be a...
2021-03-29 | MTBLS2205 | MetaboLights
ProteomicsEnvironmental interactions and epistasis are revealed in the proteomic responses to complex stimuli
Ultimately, the genotype of a cell and its interaction with the environment determine the cell’s biochemical state. While the cell’s response to a single stimulus has been studied extensively, a conceptual framework to model the effect of multiple environmental stimuli applied concurrently is not a...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2015-07-20 | PXD002371 | Pride
Yeast Environmental epistasis Mudpit Environmental interaction Saccharomyces cerevisiae Itraq 
GenomicsOrigins and breadth of pairwise epistasis in an α-helix of β-lactamase TEM-1
epistasis in an α-helix of β-lactamase TEM-1
PRJEB104463 | ENA
GenomicsMitochondrial - Y Chromosome Epistasis in Drosophila melanogaster
Mitochondrial - Y Chromosome Epistasis in Drosophila melanogaster
PRJNA649569 | ENA
UnknownConsiderations in the search for epistasis.
Not available
S-EPMC11574992 | biostudies-literature
GenomicsA Quantitative Epistasis Framework For Interrogating the Network of Enhancers
A Quantitative Epistasis Framework For Interrogating the Network of Enhancers
PRJNA674378 | ENA
GenomicsMycobacterium tuberculosis Fitness Epistasis
Epistasis between drug resistance-conferring mutations in Mycobacterium tuberculosis
PRJEB94519 | ENA
UnknownEpistasis and Entropy.
Not available
S-EPMC5178987 | biostudies-literature
UnknownEvolutionary footprint of epistasis.
Not available
S-EPMC6177197 | biostudies-literature
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