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MetabolomicsMulti-omic Landscape of Airway Microbe-Host Interactions in Chronic Obstructive Pulmonary Disease

The mechanistic role of the airway microbiome in chronic obstructive pulmonary disease (COPD) remains largely unexplored. We present a landscape of airway microbe-host interactions in COPD by an in-depth profiling of sputum metagenome, metabolome, host transcriptome and proteome from 99 COPD pati...

2022-06-20 | MTBLS4017 | MetaboLights
TranscriptomicsInterplay of host microbiota, genetic perturbations, and inflammation promote local development of intestinal neoplasms in mice
The preferential localization of some neoplasms, such as serrated polyps, in specific areas of the intestine suggests that non-genetic factors may be important for their development. To test this hypothesis, we took advantage of transgenic mice that expressed HB-EGF throughout the intestine, but dev...
ORGANISM(S): Mus musculus 
2014-02-12 | E-GEOD-47735 | biostudies-arrayexpress
ProteomicsCC16 drives VLA-2-dependent SPLUNC1 expression.
Rationale: CC16 (Club Cell Secretory Protein) is a protein produced by club cells and other non-ciliated epithelial cells within the lungs. CC16 has been shown to protect against the development of obstructive lung diseases and attenuate pulmonary pathogen burden. Despite recent advances in understa...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-13 | PXD046830 | Pride
Short palate lung and nasal epithelial clone 1 Club cell secretory protein Epithelial-driven host responses 
UnknownLinear ubiquitin assembly complex regulates lung epithelial-driven responses during influenza infection.
Not available
S-EPMC7269564 | biostudies-literature
ProteomicsPhosphoproteomic Survey of Human iPSC-derived Lung Alveolar Type 2 Cells Reveals Cytopathogenic Host Responses to SARS-CoV-2 Infection
Human transmission of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the causative pathogen of the coronavirus disease 2019 (COVID-19) pandemic, is exerting a massive health and socioeconomic burden. The virus infects pneumocytes, also known as alveolar epithelial type 2 (AT2) cells, ...
ORGANISM(S): Homo sapiens (Human) Severe acute respiratory syndrome coronavirus 2 
2020-11-20 | PXD020183 | Pride
Sars-cov-2 Mass spectrometry Human alveolar cells Drug targets Infection Phosphoproteomics Covid-19 Signaling Host pathways Pathogenesis Lung organoids 
UnknownEpithelial transcription factor Elf3 mediates host immune responses to microbiota and protects against aerocystitis in zebrafish.
Not available
S-EPMC12691682 | biostudies-literature
TranscriptomicsRNA-seq of human intestinal organoids infected with Salmonella enterica at 2.5h and 8h post infection
The purpose of this experiment was to identify intestinal epithelial responses to various strains of Salmonella enterica. Human intestinal organoids were infected with three serovars of Salmonella; Typhimurium, Enteritidis and Typhi, as well as type 3 secretion system -1 and -2 mutants in Typhimuriu...
ORGANISM(S): Homo sapiens 
2021-10-01 | E-MTAB-10451 | biostudies-arrayexpress
UnknownEpithelial chemerin-CMKLR1 signaling restricts microbiota-driven colonic neutrophilia and tumorigenesis by up-regulating lactoperoxidase.
Not available
S-EPMC9304024 | biostudies-literature
ProteomicsPneumococcus suppresses host inflammatory response through COMMD2 mediated NF-κB degradation by aggrephagy
NF-κB driven cellular immunity is essential for both pro- and anti-inflammatory responses to microbes, which makes it one of the most frequently targeted pathways by bacteria during pathogenesis. How NF-κB tunes the epithelial response to Streptococcus pneumoniae across the spectrum of commensal to ...
ORGANISM(S): Streptococcus pneumoniae TIGR4 
2026-09-07 | PXD043886 | Pride
Commd2 Nf-κb degradation 
GenomicsTranscriptomic responses of human lung epithelial cells to crude and purified bacteriophage preparations
Bacteriophage-host transcriptomics in A549 cells
PRJEB115326 | ENA
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