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UnknownCPEB1 mediates epithelial-to-mesenchyme transition and breast cancer metastasis.
Not available
S-EPMC4809797 | biostudies-literature
TranscriptomicsTranscription profiling of mouse Tie2-Cre transgene endothelial cells with inactivated Gata4 reveals development of heart valves requires Gata4 expression in endothelial-derived cells
Cardiac malformations due to aberrant development of the atrioventricular (AV) valves are among the most common forms of congenital heart disease. At localized swellings of extracellular matrix known as the endocardial cushions, the endothelial lining of the heart undergoes an epithelial to mesenchy...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5298 | biostudies-arrayexpress
ProteomicsCRISPR-Cas9-mediated ALMS1 knockout inhibits TGF-β signalling and epithelial-mesenchyme transition.
In this project we evaluated the proteomic profiling with TGF-β stimuli at 24h in a CRISPR-Cas9 model for ALMS1 gene in HeLa cells. Proteomic results showed a majority inhibition of downstream regulated pathways by the TGF-β, associating the protein coding genes (PCG) with processes like focal adhes...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD024964 | Pride
Epithelial-mesenchyme transition Tgf-β Alms1 Hela Fibrosis Alström syndrome Lc-esi-ms/ms 
TranscriptomicsTMPRSS2:ERG promotes invasiveness and epithelial to mesenchymal transition in prostate cancer model
Recently, a frequent chromosomal aberration fusing Androgen regulated TMPRSS2 promoter and the ERG gene (T/ERG) was discovered in prostate cancer. Several studies demonstrated cooperation between the T/ERG and other defective pathways in cancer progression however, the biological mechanism by which ...
ORGANISM(S): Homo sapiens 
2010-12-30 | E-GEOD-22010 | biostudies-arrayexpress
TranscriptomicsTranscription factors OVOL1 and OVOL2 induce the mesenchymal to epithelial transition in human cancer
This paper shows, for the first time, a novel function of the OVO-like proteins (OVOL1and OVOL2) as critical inducers of mesenchymal to epithelial transition (MET) in human cancer. Examination of the effects of OVOL1 and OVOL2 overexpression in a prostate cancer model.
ORGANISM(S): Homo sapiens 
2013-08-01 | E-GEOD-48230 | biostudies-arrayexpress
TranscriptomicsA genome-wide expression comparison of productive and unproductive airway epithelial repair
Defective epithelial repair in the setting of chronic lung disease has been suggested to contribute to uncontrolled extracellular matrix (ECM) deposition and development of fibrosis. We sought to directly test this hypothesis through gene expression profiling of total lung RNA isolated from mouse mo...
ORGANISM(S): Mus musculus 
2009-08-18 | E-GEOD-17693 | biostudies-arrayexpress
UnknownSingle-cell RNA sequencing and lineage tracing confirm mesenchyme to epithelial transformation (MET) contributes to repair of the endometrium at menstruation.
Not available
S-EPMC9873258 | biostudies-literature
TranscriptomicsTranscription profiling of mouse medial edge epithelial cells during palatal adherence and epithelial-mesenchymal transformation
Genomic analysis was performed to distinguish expression changes in murine medial edge epithelial cells during both palatal adherence and epithelial-mesenchymal transformation (EMT). Assessment of changes between sample 0 hours and sample 12 hours represent palatal adherence. Changes between sample ...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-2537 | biostudies-arrayexpress
UnknownVersican mediates mesenchymal-epithelial transition.
Not available
S-EPMC1415306 | biostudies-literature
UnknownInhibition of histone deacetylase impacts cancer stem cells and induces epithelial-mesenchyme transition of head and neck cancer.
Not available
S-EPMC3603970 | biostudies-literature
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