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MetabolomicsSingle-cell lipidomic analysis of the Epithelial-Mesenchymal Transition (EMT) using MALDI-MSI

EMT is a metastasis-promoting process whose heterogeneity has been extensively studied at a gene expression level. EMT also involves reprogramming of lipid metabolism, however there has been little focus on heterogeneity on the lipid level. Here, we use MALDI-MSI to determine the levels of variou...

2026-04-15 | MTBLS12650 | MetaboLights
GenomicsHistone modification analysis in TGFbeta/TNFalpha treated A549 spheroid cultures
We studied the extent of chromatin remodeling in an in-vitro model of the epithelial-mesenchymal transition (EMT). EMT is induced in spheroid cultures (3D) using simultaneously two cytokines: TGFbeta and TNFalpha. The epithelial-mesenchymal transition (EMT) is a cellular de-differentiation process t...
ORGANISM(S): Homo sapiens 
2013-09-12 | E-GEOD-42374 | biostudies-arrayexpress
TranscriptomicsTranscription factors OVOL1 and OVOL2 induce the mesenchymal to epithelial transition in human cancer
This paper shows, for the first time, a novel function of the OVO-like proteins (OVOL1and OVOL2) as critical inducers of mesenchymal to epithelial transition (MET) in human cancer. Examination of the effects of OVOL1 and OVOL2 overexpression in a prostate cancer model.
ORGANISM(S): Homo sapiens 
2013-08-01 | E-GEOD-48230 | biostudies-arrayexpress
TranscriptomicsPrognostic signature of epithelial-mesenchymal transition in breast cancer
Epithelial-mesenchymal transition (EMT), a switch of polarized epithelial cells to a migratory, fibroblastoid phenotype, is considered a key process driving tumor cell invasiveness and metastasis. Using breast cancer cell lines as a model system, we sought to discover gene-expression signatures of ...
ORGANISM(S): Homo sapiens 
2010-04-11 | E-GEOD-13915 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse adult ovarian surface epithelial cells in epithelial to mesenchymal transition
Adult Ovarian Surface Epithelium (OSE) retains the ability to undergo Epithelial to Mesenchymal Transition (EMT). We established a cell culture of murine adult OSE in their epithelial state, and we induced EMT by modifying their culture conditions. In this experiment we compare the transcriptional p...
ORGANISM(S): Mus musculus 
2010-03-02 | E-GEOD-19947 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of NSCLC cell lines upon TGFb-induced epithelial-mesenchymal transition (EMT)
Epithelial-mesenchymal transition has been implicated in tumor metastasis, cancer drug resistance and cancer stem cell features. In this study, we examined gene expression profiles of three non-small cell lung cancer cell lines, before and after experimentally induced EMT. We modeled epitheial-mese...
ORGANISM(S): Homo sapiens 
2014-11-19 | E-GEOD-49644 | biostudies-arrayexpress
TranscriptomicsAn epithelial-mesenchymal transition (EMT) gene signature predicts resistance to erlotinib and PI3K pathway inhibitors and identifies Axl as a novel EMT marker in non-small cell lung cancer.
Epithelial/mesenchymal transition (EMT) is associated with loss of cell adhesion molecules, such as E-cadherin, and increased invasion, migration, and proliferation in epithelial cancers. In non-small cell lung cancer (NSCLC), EMT is associated with greater resistance to EGFR inhibitors. However, it...
ORGANISM(S): Homo sapiens 
2012-10-25 | E-GEOD-33072 | biostudies-arrayexpress
GenomicsWhole genome bisulfite sequencing of MDCK cells, before and after TGFB-induced epithelial-mesenchymal transition
Whole genome bisulfite sequencing of MDCK cells, before and after TGFB-induced epithelial-mesenchymal transition Sequencing of bisulfite converted DNA from MDCK cells untreated, and after a 30 days treatment with TGF beta
ORGANISM(S): Canis lupus familiaris 
2014-08-14 | E-GEOD-43697 | biostudies-arrayexpress
ProteomicsProteomic analysis identifies novel pathways linking epithelial-to-mesenchymal transition with resistance to HER2-targeted therapy
Resistance to Human Epidermal Growth Factor Receptor (HER)-targeted cancer therapies appear to be occurring via common pathways, despite differences in their mechanism of action. This suggests that combination therapies targeting alternative pathways will be needed to overcome resistance. We have us...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080706 | MassIVE
MetabolomicsEMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer

The involvement of membrane-bound solute carriers (SLCs) in neoplastic transdifferentiation processes is poorly defined. Here, we examined changes in the SLC landscape during epithelial-mesenchymal transition (EMT) of pancreatic cancer cells. We show that two SLCs from the organic anion...

2021-10-15 | MTBLS1925 | MetaboLights
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