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TranscriptomicsHuman Hematopoietic and Leukemic Stem Cell Gene Expression Profiles
This SuperSeries is composed of the following subset Series: GSE30375: Gene expression data from sorted and unsorted primary human acute myeloid leukemia (AML) samples GSE30376: Gene expression data from sorted primary human cord blood samples Refer to individual Series
ORGANISM(S): Homo sapiens 
2011-08-27 | E-GEOD-30377 | biostudies-arrayexpress
TranscriptomicsGene expression data from sorted primary human cord blood samples
Experiments using xenografts show that some solid tumours and leukemias are organized as cellular hierarchies sustained by cancer stem cells (CSC). Despite promise, the relevance of the CSC model to human disease remains uncertain. Here we show that acute myeloid leukemia (AML) follows a CSC model b...
ORGANISM(S): Homo sapiens 
2011-08-27 | E-GEOD-30376 | biostudies-arrayexpress
TranscriptomicsGene expression data from sorted and unsorted primary human acute myeloid leukemia (AML) samples
Experiments using xenografts show that some solid tumours and leukemias are organized as cellular hierarchies sustained by cancer stem cells (CSC). Despite promise, the relevance of the CSC model to human disease remains uncertain. Here we show that acute myeloid leukemia (AML) follows a CSC model b...
ORGANISM(S): Homo sapiens 
2011-08-27 | E-GEOD-30375 | biostudies-arrayexpress
TranscriptomicsA revised map of the human progenitor hierarchy reveals origin of macrophages and dendritic cells in early lymphoid development
The classical model of hematopoiesis posits the segregation of lymphoid and myeloid lineages as the earliest fate decision. The validity of this model has recently been questioned in the mouse, however little is known concerning lineage potential of human progenitors. Here we provide a comprehensive...
ORGANISM(S): Homo sapiens 
2010-06-23 | E-GEOD-21973 | biostudies-arrayexpress
TranscriptomicsDiscovery of novel recurrent mutations and rearrangements in early T-cell precursor acute lymphoblastic leukemia by whole genome sequencing
Early T-cell precursor acute lymphoblastic leukaemia (ETP ALL) is an aggressive malignancy of unknown genetic basis. We performed whole genome sequencing of tumour and normal DNA from 12 children with ETP ALL and assessed the frequency of somatic alterations in 52 ETP and 42 non-ETP T-ALL samples by...
ORGANISM(S): Homo sapiens 
2011-11-23 | E-GEOD-28703 | biostudies-arrayexpress
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