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TranscriptomicsGene expression of RonTK-/- mammary glands compared to RonTK+/+ controls during development
RON WT and RON KO at 5, 6, 7 week virgin mammary glands In the study, we demonstrated that RON regulates mammary gland branching morphogenesis in pubertal development associated with changes in gene expression. Keywords: Pubertal mammary glands In the study, we hybridized RNA from 5, 6, 7 week old ...
ORGANISM(S): Mus musculus 
2009-06-16 | E-GEOD-16629 | biostudies-arrayexpress
TranscriptomicsEpithelial mesenchymal transition using doxycycline-inducible Snail, Zeb1, TGFbeta or Vector in H358 NSCLC cell line
Epithelial – mesenchymal transition (EMT) is an important contributor to the invasion and metastasis of epithelial-derived cancers. While considerable effort has focused in the regulators involved in the transition process, we have focused on consequences of EMT to prosurvival signaling. Changes in ...
ORGANISM(S): Homo sapiens 
2019-01-16 | GSE125113 | GEO
TranscriptomicsDistinct effects of topoisomerase II inhibitors on tumor cell lines (part 1)
One major class of anti-cancer drugs targets topoisomerase II to induce DNA double-strand breaks and cell death of fast growing cells. Here, we compare three members of this class - the antracyclines doxorubicin and aclarubicin, and a chemically unrelated compound, etoposide. Aclarubicin does not i...
ORGANISM(S): Homo sapiens 
2013-06-04 | E-GEOD-33624 | biostudies-arrayexpress
GenomicsEpithelial mesenchymal transition using doxycycline-inducible Snail, Zeb1, TGFbeta or Vector in H358 NSCLC cell line
Epithelial mesenchymal transition using doxycycline-inducible Snail, Zeb1, TGFbeta or Vector in H358 NSCLC cell line
PRJNA515267 | ENA
TranscriptomicsTranscriptome of early postnatal brain development of eIF2B-R132H/R132H mutant mice relative to wild-types.
Genome-wide mRNA expression in brains of wild-type and eIF2B-R132H/R132H mutant mice (Geva et al., BRAIN 133 (8), 2010) profiled at postnatal (P) days 1, 18 and 21 to reflect the early proliferative stage prior to white matter establishment (P1) and the peak of oligodendrocye differentiation and mye...
ORGANISM(S): Mus musculus 
2011-11-14 | E-GEOD-32201 | biostudies-arrayexpress
TranscriptomicsDistinct effects of topoisomerase II inhibitors on tumor cell lines (part 2)
One major class of anti-cancer drugs targets topoisomerase II to induce DNA double-strand breaks and cell death of fast growing cells. Here, we compare three members of this class - the antracyclines doxorubicin and aclarubicin, and a chemically unrelated compound, etoposide. Aclarubicin does not i...
ORGANISM(S): Homo sapiens 
2013-06-04 | E-GEOD-33625 | biostudies-arrayexpress
TranscriptomicsGene expression profile of chicken lung in response to Avian influenza virus challenge in broiler chickens
To determine the host response to AIV in chicken lungs, a whole chicken genome array was used to analyze RNA isolated from chicken lungs infected with AIV (4dpi) or medium control (NS). Dual-color, direct comparisons were carried between AIV infected and non-infected controls. Each comparison includ...
ORGANISM(S): Gallus gallus 
2012-06-06 | E-GEOD-38197 | biostudies-arrayexpress
TranscriptomicsmiR-634 restores drug sensitivity in resistant ovarian cancer cells by targeting the Ras-MAPK pathway
The development of drug resistance is still a major impediment for the successful treatment of cancer, such as advanced stage ovarian cancer, which has a 5-year survival rate of only 30%. The molecular processes that contribute to resistance have been extensively studied, however, not much is known ...
ORGANISM(S): Homo sapiens 
2014-02-04 | E-GEOD-54665 | biostudies-arrayexpress
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