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TranscriptomicsThe genetic architecture of the genome-wide transcriptional response to ER stress in the mouse
Endoplasmic reticulum (ER) stress occurs when misfolded proteins accumulate in the ER. The cellular response to ER stress involves complex transcriptional and translational changes, important to the survival of the cell. ER stress is a primary cause and a modifier of many human diseases. A first ste...
ORGANISM(S): Mus musculus 
2014-12-02 | E-GEOD-63756 | biostudies-arrayexpress
GenomicsChIP-Seq of human MCF-7 cells with ER-alpha and ER-beta anitbodies following estrogen treatment
We performed chromatin immunoprecipitation (ChIP) with overnight with antibodies against the C-terminus (HC-20, from Santa Cruz Biotechnology, Europe) or the N-terminus (anti-Estrogen Receptor 18-32, from SigmaAldrich, Italy) of human ER-alpha with or without estrogen treatment for 45 minutes on TAP...
ORGANISM(S): Homo sapiens 
2010-12-01 | E-MTAB-345 | biostudies-arrayexpress
MetabolomicsER stress inhibits liver fatty acid oxidation while unmitigated stress leads to anorexia-induced lipolysis and both liver and kidney steatosis
The unfolded protein response (UPR), induced by endoplasmic reticulum (ER) stress, regulates the expression of factors that restore protein folding homeostasis. However, in the liver and kidney, ER stress also leads to lipid accumulation, accompanied at least in the liver by transcriptional suppress...
2017-06-23 | MTBLS472 | MetaboLights
TranscriptomicsAcute lung injury results from innate sensing of viruses by an ER stress pathway
Incursions of new pathogenic viruses into humans from animal reservoirs are occurring with alarming frequency. The molecular underpinnings of immune recognition, host responses, and pathogenesis in this setting arepoorly understood. We studied pandemic influenza viruses to determine the mechanism by...
ORGANISM(S): Mus musculus 
2015-07-06 | E-GEOD-65075 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human MCF-7 cells with ER-beta tagged with TAP-tag at the C-term or N-term or expressing ER-alpha tagged
MCF-7 TET Off cells (MCF-7 wt) were used to produce stable clones expressing ER-beta tagged with TAP-tag respectively at the C-term and at the N-term (C-TAP-ER-beta and N-TAP-ER-beta) or expressing ER-alpha tagged (C-TAP-ER-alpha). All were grown in Dulbecco's modified Eagle's medium (DMEM). Then c...
ORGANISM(S): Homo sapiens 
2011-10-11 | E-TABM-1052 | biostudies-arrayexpress
no omics definedMicroRNA profiling by array of human MCF-7 breast cancer cells with ER-beta tagged at the C-terminal or N-terminal and treated with 17-beta-estradiol
Human estrogen-responsive breast cancer cell line MCF-7 TET Off (MCF-7 wt) were used to produce stable clones expressing ER-beta tagged with TAP-tag respectively at the C-term and at the N-term (C-TAP-ER-beta and N-TAP-ER-beta) or expressing ER-alpha tagged (C-TAP-ER-alpha) as previously described.(...
ORGANISM(S): Homo sapiens 
2011-07-29 | E-TABM-1055 | biostudies-arrayexpress
ProteomicsFam20C interactome in the secretory pathway under ER stress
Accumulated unfolded proteins in the endoplasmic reticulum (ER) will trigger the unfolded protein response (UPR) to increase protein-folding capacity. The ER proteostasis and UPR signaling should be precisely and timely regulated. In the project, by unbiased proteomics analysis, we identify that the...
ORGANISM(S): Homo sapiens (Human) 
2020-03-02 | PXD016619 | Pride
Fam20c Pdi Er stress Phosphorylation 
TranscriptomicsA role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span
This SuperSeries is composed of the following subset Series: GSE4093: Resveratrol treatment of daf-16 mutant C. elegans GSE4094: N2 worms treated with Resveratrol GSE4095: Sir-2.1 low copy transgenic Abstract: C. elegans SIR-2.1, a member of the Sir-2 family of NAD(+)-dependent protein deacetylases...
ORGANISM(S): Caenorhabditis elegans 
2006-03-07 | E-GEOD-4402 | biostudies-arrayexpress
ProteomicsTurboID-based proximity labeling of ER-localized TMEM120A/B interactome in Oleic Acid-treated HEK293T cells
Raw mass spectrometry data (.d raw data from Bruker) supporting the study: "A conserved ER protein prevents lipotoxicity by stimulating the key enzyme in glycerolipid synthesis". This dataset contains LC-MS/MS raw files from a proximity labeling experiment (TurboID) designed to identify interacting ...
ORGANISM(S): Homo sapiens (Human) 
2026-04-09 | PXD075982 | Pride
Proximity labeling Turboid Tag Lipid droplet 
TranscriptomicsTranscription profiling by array of human MCF-7 breast cell clones expressing ER-beta tagged with TAP-tag at the C-terminal or N-terminal
MCF-7 TET Off cells (MCF-7 wt) were used to produce stable clones expressing ER-beta tagged with TAP-tag respectively at the C-term and at the N-term (C-TAP-ER-beta and N-TAP-ER-beta) or expressing ER-alpha tagged (C-TAP-ER-alpha) as previously described.Cells were cultured in standard growth condit...
ORGANISM(S): Homo sapiens 
2011-10-11 | E-TABM-1053 | biostudies-arrayexpress
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