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MetabolomicsDeficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease
Non-alcoholic fatty liver is the most common liver disease worldwide. Here, we show that the mitochondrial protein mitofusin 2 (Mfn2) protects against liver disease. Reduced Mfn2 expression was detected in liver biopsies from patients with non-alcoholic steatohepatitis (NASH). Moreover, reduced Mfn2...
2018-01-25 | MTBLS600 | MetaboLights
TranscriptomicsRetinoid X Receptor activation reverses the age-related deficiency in myelin debris phagocytosis and enhances remyelination
The efficiency of central nervous system (CNS) remyelination declines with age. This is in part due to an age-associated decline in the phagocytic removal of myelin debris, which contains inhibitors of oligodendrocyte progenitor cell differentiation. In this study we show that expression of genes i...
ORGANISM(S): Homo sapiens 
2015-11-04 | E-GEOD-66988 | biostudies-arrayexpress
TranscriptomicsGeneration of hematopoietic progenitor cell lines with myeloid and lymphoid potential using a conditional form of Hoxb8
Investigation of immune cell differentiation and function is limited by shortcomings of suitable and scalable experimental systems. Although forced expression of certain Hox genes allows immortalization of hematopoietic progenitor cells, their differentiation potential is limited to select myeloid l...
ORGANISM(S): Mus musculus 
2013-06-05 | E-GEOD-45759 | biostudies-arrayexpress
ProteomicsExperimental validation of a central carbon metabolic model in Aspergillus niger to enable metabolic engineering of a fungal cell factory
The influence of selected pentose catabolic pathway (PCP) deletion strains on growth of plant biomass and re-routing of sugar catabolism was addressed to gain a better understanding of the flexibility of the fungus Aspergillus niger in using plant biomass-derived monomers. The transcriptome, metabol...
ORGANISM(S): Aspergillus Niger (ncbitaxon:5061) 
2020-12-17 | MSV000086614 | MassIVE
TranscriptomicsTranscription profiling of mouse liver response to quercetin in WT and POR-null mice
Using mice deficient in hepatic cytochrome-P450 oxidoreductase (POR), which disables the liver cytochrome P450 system, the metabolism and biological response of the anti-carcinogenic flavonoid, quercetin, was examined. Profiling circulating metabolites revealed similar profiles over 72 h in wild typ...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-4259 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse ileum response to quercetin in WT and POR-null mice
Using mice deficient in hepatic cytochrome-P450 oxidoreductase (POR), which disables the liver cytochrome P450 system, the metabolism and biological response of the anti-carcinogenic flavonoid, quercetin, was examined. Profiling circulating metabolites revealed similar profiles over 72 h in wild typ...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-4257 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse POR-null and wild type jejunum response to quercetin
Using mice deficient in hepatic cytochrome-P450 oxidoreductase (POR), which disables the liver cytochrome P450 system, the metabolism and biological response of the anti-carcinogenic flavonoid, quercetin, was examined. Profiling circulating metabolites revealed similar profiles over 72 h in wild typ...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-4258 | biostudies-arrayexpress
TranscriptomicsDecay-initiating endoribonucleolytic cleavage by RNase Y is kept under tight control via sequence preference and sub-cellular localisation
Bacteria depend on efficient RNA turnover to rapidly alter gene expression, essentially for responding to changing conditions. Nevertheless, remarkably few details are known about the rate-limiting steps in targeting and decay of RNA. The membrane-anchored endoribonuclease RNase Y is a virulence fac...
ORGANISM(S): Staphylococcus aureus 
2015-09-01 | E-GEOD-68811 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse colon response to quercetin in WT and POR-null animals
Using mice deficient in hepatic cytochrome-P450 oxidoreductase (POR), which disables the liver cytochrome P450 system, the metabolism and biological response of the anti-carcinogenic flavonoid, quercetin, was examined. Profiling circulating metabolites revealed similar profiles over 72 h in wild typ...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-4256 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of colon, ileum, jejunum and liver from wild type and hepatic cytochrome P-450 reductase null mice treated with quercetin to identify differential transcriptional responses to quercetin.
This SuperSeries is composed of the following subset Series: GSE4256: Colon transcriptional response to quercetin in WT and POR-null mice; GSE4257: Ileum transcriptional response to quercetin in WT and POR-null mice; GSE4258: Jejunum transcriptional response to quercetin in WT and POR-null mice; GSE...
ORGANISM(S): Mus musculus 
2007-11-06 | E-GEOD-4262 | biostudies-arrayexpress
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