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GenomicsER body and indole glucosinolate modulaing microbiota assembly
ER body and indole glucosinolate modulaing microbiota assembly
PRJEB54088 | ENA
TranscriptomicsAcute lung injury results from innate sensing of viruses by an ER stress pathway
Incursions of new pathogenic viruses into humans from animal reservoirs are occurring with alarming frequency. The molecular underpinnings of immune recognition, host responses, and pathogenesis in this setting arepoorly understood. We studied pandemic influenza viruses to determine the mechanism by...
ORGANISM(S): Mus musculus 
2015-07-06 | E-GEOD-65075 | biostudies-arrayexpress
TranscriptomicsUBF Is An Epigenetic Factor Required For Ribosomal RNA Gene Activity And Preinitiation Complex Assembly But Not For Nucleolar Body Formation
Upstream Binding Factor (UBF) is a unique multi-HMGB-box protein first identified as a co-factor in RNA polymerase I (RPI/PolI) transcription. However, its poor DNA sequence selectivity and its ability to generate nucleosome-like nucleoprotein complexes suggest a more generalized role in chromatin s...
ORGANISM(S): Mus musculus 
2014-08-19 | E-GEOD-55450 | biostudies-arrayexpress
MetabolomicsER stress inhibits liver fatty acid oxidation while unmitigated stress leads to anorexia-induced lipolysis and both liver and kidney steatosis
The unfolded protein response (UPR), induced by endoplasmic reticulum (ER) stress, regulates the expression of factors that restore protein folding homeostasis. However, in the liver and kidney, ER stress also leads to lipid accumulation, accompanied at least in the liver by transcriptional suppress...
2017-06-23 | MTBLS472 | MetaboLights
TranscriptomicsGenome-wide mRNA profiling for identification of specific body fluid markers
Genome-wide expression profiling of four kinds of body fluid samples (blood, saliva, semen and vaginal swab). The purpose of the present study was selection of specific mRNA markers for identification of the four body fluids. Results provide important information about gene expression level of each ...
ORGANISM(S): Homo sapiens 
2013-01-22 | E-GEOD-34844 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human cell cancer line treated with bortezomib or Eeyarestatin I (EerI) reveals ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3 only protein NOXA in cancer cells
The ubiquitin-proteasome system (UPS) has recently emerged as a major target for drug development in cancer therapy. The proteasome inhibitor bortezomib has clinical activity in multiple myeloma and mantle cell lymphoma. Here we report that Eeyarestatin I (EerI), a chemical inhibitor that blocks ER-...
ORGANISM(S): Homo sapiens 
2009-02-28 | E-GEOD-14003 | biostudies-arrayexpress
GenomicsChIP-Seq of ERalpha and RNA polymerase II defines genes differentially responding to ligands
We used ChIP-Seq to map ERalpha binding sites and to profile changes in RNA polymerase II (RNAPII) occupancy in MCF-7 cells in response to estradiol (E2), tamoxifen or fulvestrant. We identified 10,205 high confidence ERalpha binding sites in response to E2 of which 68% contained an estrogen respons...
ORGANISM(S): Homo sapiens 
2009-03-09 | E-GEOD-14664 | biostudies-arrayexpress
ProteomicsAnalyzing the ER stress response in ALS patient derived motor neurons identifies druggable neuroprotective targets
Supporting MS data files for paper (doi:10.3389/fncel.2023.1327361) by Watts M.E. et al., titled "Analyzing the ER stress response in ALS patient derived motor neurons identifies druggable neuroprotective targets". See attached pdf for index of MS files uploaded.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-10-25 | MSV000093190 | MassIVE
TranscriptomicsER in liver
In order to elucidate the mechanism underlying ER control of liver metabolic function, we investigated the genetic programs controlled by the hepatic receptor during the physiological fluctuation of circulating E2 in adult female mice. To this aim, we used Affymetrix GeneChip Arrays and compared the...
ORGANISM(S): Mus musculus 
2012-07-04 | E-MEXP-3504 | biostudies-arrayexpress
TranscriptomicsER in Liver - 2
Liver transcriptome was analyzed at proestrus (P) and metestrus (M) in liver IGF-1-/- or LID mice. In order to elucidate the mechanism underlying ER control of liver metabolic function, we investigated the genetic programs controlled by the hepatic receptor during the physiological fluctuation of ci...
ORGANISM(S): Mus musculus 
2012-07-04 | E-MEXP-3505 | biostudies-arrayexpress
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