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ProteomicsA novel translocon for biogenesis of multi-pass membrane proteins
A novel 370 kDa translocon comprising Sec61 and five accessory factors acting co-translationally with ribosomes to fold and insert multi-pass membrane proteins was identified, purified and analyzed structurally by single particle cryo-EM and cross-linking mass spectrometry. The purified ribosome-tr...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-07-08 | MSV000084065 | MassIVE
UnknownThe ER Membrane Protein Complex Promotes Biogenesis of Dengue and Zika Virus Non-structural Multi-pass Transmembrane Proteins to Support Infection.
Not available
S-EPMC6521869 | biostudies-literature
UnknownAn ER translocon for multi-pass membrane protein biogenesis.
Not available
S-EPMC7505659 | biostudies-literature
UnknownStructure of the ER membrane complex, a transmembrane-domain insertase.
Not available
S-EPMC7442705 | biostudies-literature
UnknownThe ER membrane protein complex is required to ensure correct topology and stable expression of flavivirus polyproteins.
Not available
S-EPMC6756788 | biostudies-literature
TranscriptomicsEffect of N-glycosylated of SIDT1 on gene expression of human embryonic kidney (HEK293T) cells
The mammalian SID-1 transmembrane family member 1 (SIDT1), are multi-pass transmembrane proteins that mediate the cellular uptake and intracellular trafficking of nucleic acids, playing important roles in the immune response and tumorigenesis. We here report N-glycosylation as a key regulator of SID...
ORGANISM(S): Homo sapiens 
2023-08-09 | GSE239877 | GEO
UnknownDirect interaction between the transmembrane helices stabilize cytochrome P450 2B4 and cytochrome b5 redox complex.
Not available
S-EPMC10838600 | biostudies-literature
ProteomicsProtein interactions of TMEM147 and TMEM129 proteins from HeLa cells in co-IP experiments
IP/MS waw used to identify protein interactions for TMEM147.
ORGANISM(S): Homo sapiens (Human) 
2020-08-03 | PXD019598 | Pride
E3 ubiquitin-protein ligase tm129 Protein nifie 14 Er multi-pass transmembrane proteins 
ProteomicsEndogenous interactors of the natural trapping mutant TMX5/TXNDC15
The endoplasmic reticulum (ER) is the organelle of nucleated cells that produces lipids, sugars and proteins. More than 20 ER-resident members of the Protein Disulfide Isomerase (PDI) family regulate formation, isomerization and disassembly of covalent bonds in newly synthesized polypeptides. The PD...
ORGANISM(S): Homo sapiens (Human) 
2024-09-27 | PXD054716 | Pride
Endoplasmic reticulum  erp44  mixed disulfides  pdi family  tmx5/txnd15 
UnknownBioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters.
Not available
S-EPMC8490997 | biostudies-literature
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