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MetabolomicsTargeted metabolomic profiling of myocardial remodeling after STEMI

Early detection of myocardial remodeling is essential for optimizing outcomes in patients with ST-segment elevation myocardial infarction (STEMI). However, reliable biomarkers for predicting STEMI myocardial remodeling remain scarce.

Targeted metabolomic profiling was performed on plasma ...

2025-09-02 | MTBLS10634 | MetaboLights
MetabolomicsTear lipidomics profiling reveals inflammatory dry eye disease-associated lipid metabolic remodeling at the ocular surface
This study aimed to investigate whether inflammatory dry eye disease (DED) is accompanied by abnormal lipid metabolic remodeling at the ocular surface. Tear samples were collected from patients with DED and matched healthy controls. Lipidomics profiling was performed using LC–MS/MS with a standardiz...
2026-04-03 | MTBLS14218 | MetaboLights
TranscriptomicsStress-Independent Activation of XBP1s and/or ATF6 Reveals Three Functionally Distinct ER Proteostasis Environments [HEK293DYG]
The unfolded protein response (UPR) maintains endoplasmic reticulum (ER) proteostasis through the activation of transcription factors such as XBP1s and ATF6. The functional consequences of these transcription factors for ER proteostasis remain poorly defined. Here, we describe methodology that enabl...
ORGANISM(S): Homo sapiens 
2013-04-23 | E-GEOD-44950 | biostudies-arrayexpress
TranscriptomicsStress-Independent Activation of XBP1s and/or ATF6 Reveals Three Functionally Distinct ER Proteostasis Environments [HEK293DAX]
The unfolded protein response (UPR) maintains endoplasmic reticulum (ER) proteostasis through the activation of transcription factors such as XBP1s and ATF6. The functional consequences of these transcription factors for ER proteostasis remain poorly defined. Here, we describe methodology that enabl...
ORGANISM(S): Homo sapiens 
2013-04-23 | E-GEOD-44949 | biostudies-arrayexpress
ProteomicsRegulation of mRNA localization during the oocyte-to-embryo transition by regulated mRNA-endoplasmic reticulum association and remodeling of the endoplasmic reticulum
As an important post-transcriptional regulatory mechanism, asymmetric localization of mRNAs is essential for cell polarity and cell fate determination during early development. In an effort to understand localization of mRNAs encoding proteasome components during Xenopus oocyte-to-embryo transition,...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2022-12-15 | PXD033018 | Pride
Xenopus laevis Microsome. oocyte maturation 
TranscriptomicsANGUSTIFOLIA 3 binds SWI/SNF chromatin remodeling complexes to regulate transcription during Arabidopsis leaf development
The transcriptional coactivator ANGUSTIFOLIA 3 (AN3) stimulates cell proliferation during Arabidopsis leaf development, but the molecular mechanism is largely unknown. We show here that inducible nuclear localization of AN3 during initial leaf growth results in differential expression of important t...
ORGANISM(S): Arabidopsis thaliana 
2014-09-09 | E-GEOD-42875 | biostudies-arrayexpress
ProteomicsSuper-resolution imaging reveals an ER-resident VHL–DEGS1 axis controlling ER-phagy and renal carcinoma growth
The von Hippel–Lindau tumor suppressor pVHL is best known as an E3 ligase substrate-recognition component that controls hypoxia-inducible factor stability, but how VHL mutations perturb organelle homeostasis in renal carcinoma remains unclear. Here, using live-cell super-resolution microscopy and CR...
ORGANISM(S): Homo Sapiens 
PXD082136 |
TranscriptomicsA methyl-deviator epigenotype of estrogen-receptor-positive breast carcinoma is associated with malignant biology
We broadly profiled DNA methylation in breast cancers (n=351) and benign parenchyma (n=47) for correspondence with disease phenotype using formalin-fixed paraffin-embedded (FFPE) diagnostic surgical pathology specimens. Exploratory analysis revealed a distinctive primary invasive carcinoma subclass ...
ORGANISM(S): Homo sapiens 
2011-12-08 | E-GEOD-29428 | biostudies-arrayexpress
UnknownProgrammed cortical ER collapse drives selective ER degradation and inheritance in yeast meiosis.
Not available
S-EPMC8562846 | biostudies-literature
TranscriptomicsAn Ets2-specific transcriptional program in tumor-associated macrophages promotes metastasis
Macrophages have been implicated in breast cancer progression and metastasis, but relatively little is known about the genes and pathways that are involved. Using a conditional allele of Ets2 in the mouse, we have identified Ets2 as a critical gene in tumor associated macrophages (TAMs) that specif...
ORGANISM(S): Mus musculus 
2010-01-05 | E-GEOD-12863 | biostudies-arrayexpress
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