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TranscriptomicsPhosphorylation-Regulated Cleavage of ETHYLENE INSENSITIVE2 Mediates Hormone Signaling from the Endoplasmic Reticulum to the Nucleus
Ethylene gas is essential for many developmental processes and stress responses in plants. ETHYLENE INSENSITIVE2 (EIN2), an NRAMP-homologous integral membrane protein, plays an essential role in ethylene signaling but its function remains enigmatic. Here we report that phosphorylation-regulated pro...
ORGANISM(S): Arabidopsis thaliana 
2012-10-22 | E-MTAB-4360 | biostudies-arrayexpress
ProteomicsA proteomic study on the membrane protein fraction of T cells confirms high substrate selectivity for the ER translocation inhibitor cyclotriazadisulfonamide
Cyclotriazadisulfonamide (CADA) inhibits the co-translational translocation of type I integral membrane protein human CD4 (huCD4) across the ER in a signal peptide (SP)-dependent way. Previously, sortilin was identified as a secondary substrate for CADA but showed reduced CADA sensitivity as compare...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD027712 | Pride
Cd4  cyclotriazadisulfonamide (cada)  er co-translational translocation  signal peptide  silac 
GenomicsPrinciples of ER Co-Translational Translocation Revealed by Proximity-Specific Ribosome Profiling
Principles of ER Co-Translational Translocation Revealed by Proximity-Specific Ribosome Profiling
PRJNA260073 | ENA
ProteomicsMolecular snapshots of translation and protein translocation at the ER membrane
The dynamic ribosome-translocon complex, which resides at the endoplasmic reticulum (ER) membrane, produces a major fraction of the human proteome . It governs the synthesis, translocation, membrane insertion, N-glycosylation, folding and disulfide-bond formation of nascent proteins. While individua...
ORGANISM(S): Homo sapiens (Human) 
2023-02-03 | PXD035475 | Pride
Ribosome Er membrane Elongation factor 1 
ProteomicsThe ER protein translocation channel subunit Sbh1 controls virulence of Cryptococcus neoformans
C. neoformans is an opportunistic human pathogen whose polysaccharide capsule anchored to the cell wall is critical for virulence. Biogenesis of both cell wall and capsule relies on the secretory pathway. Protein secretion begins with protein translocation across the endoplasmic reticulum (ER) membr...
ORGANISM(S): Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii) 
2023-01-27 | PXD013894 | Pride
Secretion Proteomics Cryptococcus neoformans Er 
GenomicsRNA-sequencing of human mammary epithelial cells (HMLEs) engineered to express either ER or ER-SOX4 with and without 4-OHT to induce nuclear translocation
RNA-sequencing of human mammary epithelial cells (HMLEs) engineered to express either ER or ER-SOX4 with and without 4-OHT to induce nuclear translocation
PRJNA517072 | ENA
TranscriptomicsTranscription profiling of Arabidopsis wild-type and atbzip60 mutant plants in response to the ER stress inducer tunicamycin
AtbZIP60 is one of the transcription factors involved in the endoplasmic reticulum (ER) stress response in Arabidopsis. To identify genes under the control of AtbZIP60 during ER stress, we compared the genome-wide expression profiles of wild-type and atbzip60 mutant plants in response to the ER stre...
ORGANISM(S): Arabidopsis thaliana 
2008-11-19 | E-MEXP-1753 | biostudies-arrayexpress
ProteomicsOligosaccharyltransferase is involved in targeting to ER-associated degradation
The majority of secretory proteins undergo N-glycosylation, a process catalyzed by oligosaccharyltransferase (OST), a membrane-bound protein complex that associates with the translocation channels within the endoplasmic reticulum (ER). Proteins failing quality control undergo ER-associated degradati...
ORGANISM(S): Homo sapiens (Human) 
2025-10-14 | PXD067654 | Pride
Oligosaccharyltransferase Er-associated degradation Protein quality control Protein--folding 
ProteomicsGPI glycan analysis of GPI-anchored protein from yeast
Quality controlled lipid-based protein sorting into selective ER exit sites
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast) 
2022-03-28 | PXD032852 | JPOST Repository
UnknownThe signal sequence influences post-translational ER translocation at distinct stages.
Not available
S-EPMC3793985 | biostudies-literature
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