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ProteomicsTargeting ERAP enhances anti-tumor immunity by disrupting the NKG2A/HLA-E inhibitory checkpoint
New targets that enhance anti-tumor immunity must be identified to improve the efficacy of cancer immunotherapy. Here we show that loss of endoplasmic reticulum aminopeptidase (ERAP) family proteins improves anti-tumor immunity and synergizes with immune checkpoint blockade. Mechanistically, we show...
ORGANISM(S): Homo sapiens (Human) 
2024-11-21 | PXD052031 | Pride
Human Hla-e Orbitrap Immunotherapy 
UnknownERAP-1 and ERAP-2 Variants in Liver Injury After COVID-19 mRNA Vaccination: A US Multicenter Study.
Not available
S-EPMC11296936 | biostudies-literature
UnknownEvaluating the prognostic performance of the novel ERAP score in Vietnamese acute pancreatitis patients.
Not available
S-EPMC11419453 | biostudies-literature
UnknownERAP Inhibitors in Autoimmunity and Immuno-Oncology: Medicinal Chemistry Insights.
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S-EPMC11284793 | biostudies-literature
UnknownInteraction between ERAP Alleles and HLA Class I Types Support a Role of Antigen Presentation in Hodgkin Lymphoma Development.
Not available
S-EPMC7865538 | biostudies-literature
UnknownStapled BIG3 helical peptide ERAP potentiates anti-tumour activity for breast cancer therapeutics.
Not available
S-EPMC5431889 | biostudies-literature
UnknownPrediction of Outcome in Acute Pancreatitis by the qSOFA and the New ERAP Score.
Not available
S-EPMC8976770 | biostudies-literature
UnknownERAP, KIR, and HLA-C Profile in Recurrent Implantation Failure.
Not available
S-EPMC8569704 | biostudies-literature
UnknownEvaluating the effect of rapamycin treatment in Alzheimer's disease and aging using in vivo imaging: the ERAP phase IIa clinical study protocol.
Not available
S-EPMC10993488 | biostudies-literature
ProteomicsTargeting ERAP enhances anti-tumor immunity by disrupting the NKG2A/HLA-E inhibitory checkpoint
Tsao H, Anderson S, Finn KJ, Perera J, Pass LF, Schneider EM, Jiang A, Fetterman R, Chuong CL, Kozuma K, Stickler MM, Creixell M, Klaeger S, Phulphagar KM, Rachimi S, Verzani EK, Olsson N, Dubrot J, Pech MF, Silkworth W, Lane-Reticker SK, Allen PM, Ibrahim K, Knudsen NH, Cheng AY, Long AH, Ebrahimi-...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2024-05-10 | MSV000094736 | MassIVE
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