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ModelsMammalian Cell Cycle
BACKGROUND: In breast cancer, overexpression of the transmembrane tyrosine kinase ERBB2 is an adverse prognostic marker, and occurs in almost 30% of the patients. For therapeutic intervention, ERBB2 is targeted by monoclonal antibody trastuzumab in adjuvant settings; however, de novo resistance to t...
1607 | Cell Collective
TranscriptomicsGene expression data of pHGG tumor samples
Pediatric high-grade gliomas (pHGGs) harboring the K27M mutation of H3F3A (histone H3.3) are characterized by global reduction of the repressive histone mark H3K27me3 and DNA hypomethylation. Analysis of K27M-induced changes on H3K27me3 occupancy and DNA methylation at differentially expresed genes ...
ORGANISM(S): Homo sapiens 
2014-05-14 | E-GEOD-49822 | biostudies-arrayexpress
TranscriptomicsGenes affected by manipulation of LIMT, a novel metastasis inhibiting lncRNA is suppressed by EGF and down-regulated in aggressive breast cancer
The long non coding RNA LIMT was found in our study to inhibit cellular migration in vitro and to inhibit colonization of mammary tumorigenic cells in lungs of mice in vivo. In order to uncover the mechanism enabling these tumor suppressive functions of LIMT the expression of this lncRNA was knocked...
ORGANISM(S): Homo sapiens 
2017-07-27 | E-MTAB-4821 | biostudies-arrayexpress
TranscriptomicsIdentification of differentially expressed genes in equine endometrium at day 8 and 12 of pregnancy
In order to systematically analyze the maternal, i.e. the endometrial, changes in the equine endometrium underlying the complex embryo-maternal dialogue during early pregnancy, a transcriptome study of endometrium samples from five mares at day 8 and six mares at day 12 of early pregnancy and the co...
ORGANISM(S): Equus caballus 
2010-06-30 | E-GEOD-21046 | biostudies-arrayexpress
TranscriptomicsDeep Sequencing of the Porcine Endometrial Transcriptome on Day 14 of Pregnancy
In pigs, conceptus attachment to the uterine surface epithelium starts around day 14 of pregnancy preceded by a pronounced vascularization at the implantation zones, initiating the epitheliochorial placentation. To characterize the complex transcriptome changes in the endometrium in the course of in...
ORGANISM(S): Sus scrofa 
2013-03-07 | E-GEOD-43667 | biostudies-arrayexpress
TranscriptomicsDistinct and Overlapping Gene Regulatory Networks in BMP- and HDAC-Controlled Cell Fate Determination in the Embryonic Forebrain
Both bone morphogenetic proteins (BMPs) and histone deacetylases (HDACs) have previously been established to play a role in the development of the three major cell types of the central nervous system: neurons, astrocytes, and oligodendrocytes. We have previously established a connection between thes...
ORGANISM(S): Mus musculus 
2012-06-30 | E-GEOD-31792 | biostudies-arrayexpress
TranscriptomicsGene expression data from glioblastoma tumor samples
Glioblastoma (GBM) is an incurable brain tumor carrying a dismal prognosis, which displays considerable heterogeneity. We have recently identified recurrent H3F3A mutations affecting two critical positions of histone H3.3 (K27, G34) in one-third of pediatric GBM. Here we show that each of these H3F3...
ORGANISM(S): Homo sapiens 
2012-10-16 | E-GEOD-36245 | biostudies-arrayexpress
TranscriptomicsPurification of neuronal precursors from the adult mouse brain: a comprehensive gene expression analysis
The progeny of neural stem cells in the subventricular zone (SVZ) of the adult mammalian brain consists in polysialylated NCAM-expressing immature neurons (PSA(+) cells), which migrate to the olfactory bulb (OB) to differentiate into GABAergic interneurons. We purified murine PSA(+) cells directly f...
ORGANISM(S): Mus musculus 
2007-09-21 | E-GEOD-9081 | biostudies-arrayexpress
TranscriptomicsActions and interactions of progesterone and estrogen on transcriptome profiles of the bovine endometrium
By comparison of the transcriptome profiles of infected and healthy udder tissue we analyse gene expression in the late stage of infection with E. coli 1303. Differentially expressed genes and transcription factors regulating coexpressed genes identified by SOTA clustering were used to identify key ...
ORGANISM(S): Bos taurus 
2010-09-30 | E-GEOD-16880 | biostudies-arrayexpress
TranscriptomicsAn Immune and Inflammation Signature in Prostate Tumors of Smokers (part 2)
Current smokers develop metastatic prostate cancer more frequently than nonsmokers, suggesting that a tobacco-derived factor induces metastasis. To identify smoking-induced alterations in human prostate tumors, we analyzed gene and protein expression of tumors from current, past, and never smokers a...
ORGANISM(S): Homo sapiens 
2015-04-22 | E-GEOD-68136 | biostudies-arrayexpress
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