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TranscriptomicsTranscription profiling of human MCF7 cells treated with ErbB receptor ligands EGF and heregulin at multiple doses and sampled at multiple time points reveals signal transduction pathways devotedly convey quantitative properties of the dose-dependent activation of ErbB receptor to early transcription
ErbB receptor ligands, epidermal growth factor (EGF) and heregulin (HRG), induce dose-dependent transient and sustained intracellular signaling, proliferation and differentiation of MCF-7 breast cancer cells, respectively. In an effort to delineate the ligand-specific cell determination mechanism, w...
ORGANISM(S): Homo sapiens 
2007-11-01 | E-GEOD-6462 | biostudies-arrayexpress
ModelsChen2009 - ErbB Signaling
This is A431 IERMv1.0 model described in the article Input-output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic data. William W Chen, Birgit Schoeberl, Paul J Jasper, Mario Niepel, Ulrik B Nielsen, Doug...
2024-09-02 | BIOMD0000000255 | BioModels
TranscriptomicsRNA-seq to investigate impact of treatment of KRAS mutant A549 lung adenocarcinoma cells with the multi-ERBB inhibitor Neratinib
KRAS mutation is widely presumed to confer independence from upstream RTK signalling, however emerging evidence from mouse models of lung cancer suggests that ERBB RTKs may amplify signalling through RAS isoforms and participate in mutant RAS-driven lung cancer. This is one of 3 datasets where we e...
ORGANISM(S): Homo sapiens 
2018-06-01 | E-MTAB-6483 | biostudies-arrayexpress
TranscriptomicsRNA-seq to investigate impact of treatment of KRAS mutant NCI-H2009 lung adenocarcinoma cells with the multi-ERBB inhibitor Neratinib
KRAS mutation is widely presumed to confer independence from upstream RTK signalling, however emerging evidence from mouse models of lung cancer suggests that ERBB RTKs may amplify signalling through RAS isoforms and participate in mutant RAS-driven lung cancer. This is one of 3 datasets where we e...
ORGANISM(S): Homo sapiens 
2018-06-01 | E-MTAB-6486 | biostudies-arrayexpress
TranscriptomicsRNA-seq to investigate impact of treatment of KRAS mutant NCI-H358 lung adenocarcinoma cells with the multi-ERBB inhibitor Neratinib
KRAS mutation is widely presumed to confer independence from upstream RTK signalling, however emerging evidence from mouse models of lung cancer suggests that ERBB RTKs may amplify signalling through RAS isoforms and participate in mutant RAS-driven lung cancer. This is one of 3 datasets where we e...
ORGANISM(S): Homo sapiens 
2018-06-01 | E-MTAB-6485 | biostudies-arrayexpress
ProteomicsPhosphoproteomic analysis reveals the diversity of signaling behind ErbB inhibitor-induced phenotypes
Effects of kinase inhibitors on the phosphoproteome have been rarely investigated at a whole organism level. Here we performed a phosphoproteomic analysis in embryonic zebrafish to identify the signaling pathways perturbed by the ErbB receptor tyrosine kinase inhibitors at the whole organism level. ...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2025-12-29 | PXD050396 | Pride
Erbb inhibitor Signaling pathways Zebrafish embryos Phosphoproteome 
TranscriptomicsControlled ErbB receptor dimerization
In order to better understand signaling events following receptor dimerization involving HER2, we have generated an experimental system in which ErbB dimerization can be controlled. We used gene expression microarrays to identify genes and pathways that are differentially activated by HER2 homodimer...
ORGANISM(S): Homo sapiens 
2011-05-13 | E-GEOD-22288 | biostudies-arrayexpress
TranscriptomicsConditional loss of ErbB3 delays mammary gland hyperplasias induced by mutant PIK3CA but does not affect mammary tumor latency, gene expression or signaling
Mutations in PIK3CA, the gene encoding the p110α subunit of PI3K, induce transformation of mammary epithelial cells (MEC). Studies suggest the transforming action of mutant PIK3CA requires binding to activated receptor tyrosine kinases or adaptors. We examined in transgenic mice if ErbB3, a powerful...
ORGANISM(S): Mus musculus 
2013-06-20 | E-GEOD-43037 | biostudies-arrayexpress
ModelsKemmer2022 - Disentangling ERBB Signaling in Breast Cancer Subtypes – a Model-Based Analysis
This is a dynamic pathway model capturing ERBB receptor signaling as well as downstream MAPK and PI3K signaling pathways. The effect of different growth factors and drugs on the formation of active receptor dimers is explicitly included. The model was established and calibrated on time-resolved data...
2022-05-30 | MODEL2205030001 | BioModels
TranscriptomicsTranscription profiling of MCF-7 cell lines stably overexpressing constitutively active Raf-1, constitutively active MEK, constitutively active c-erbB-2, or ligand-activatable EGFR as models of overexpressed growth factor signaling
Profiling of MCF-7 cell lines stably overexpressing constitutively active Raf-1, constitutively active MEK, constitutively active c-erbB-2, or ligand-activatable EGFR as models of overexpressed growth factor signaling, as well as control vector transfected cells (coMCF-7) and control vector transfec...
ORGANISM(S): Homo sapiens 
2007-10-02 | E-GEOD-3542 | biostudies-arrayexpress
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