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TranscriptomicsGenome-wide analysis of interleukin (IL) -6 and IL-11 responsive genes in murine gastric tumors
We performed micrarrays to analyse gene expression in spontaneously arising gastric tumors from gp130Y757F/F mutant mice (Tebbutt et al., 2002) following administration of recombinant human IL-6 or IL-11. The present study was designed to assess differences in gene expression in response to IL-6 and...
ORGANISM(S): Mus musculus 
2013-08-10 | E-GEOD-43800 | biostudies-arrayexpress
UnknownInfluence of spatial structure on protein damage susceptibility: a bioinformatics approach.
Not available
S-EPMC7925522 | biostudies-literature
UnknownKnockout of Arabidopsis thaliana VEP1, Encoding a PRISE (Progesterone 5β-Reductase/Iridoid Synthase-Like Enzyme), Leads to Metabolic Changes in Response to Exogenous Methyl Vinyl Ketone (MVK).
Not available
S-EPMC8778713 | biostudies-literature
TranscriptomicsTherapeutic interference with mTorc1 restricts inflammation-associated and Stat3-dependent gastro-intestinal tumourigenesis in mice
Gp130 receptor engagement on neoplastic cells provides a link by which an inflammatory microenvironment facilitates tumour promotion. Although hyperactivation of the gp130-dependent Stat3 signalling node is commonly observed in solid tumours, Stat3 remains a challenging therapeutic target. To mimic ...
ORGANISM(S): Mus musculus 
2013-01-29 | E-GEOD-35808 | biostudies-arrayexpress
Unknown[Enhanced quality of documentation for biologic therapy of chronic rhinosinusitis through structured digital reporting and indication?]
Not available
S-EPMC11772524 | biostudies-literature
TranscriptomicsLPS hypersensitivity of gp130 mutant mice is independent of elevated hematopoietic TLR4 signaling
The inflammatory mediator IL6 induced by LPS, which signals via TLR4, has been shown to feedback and augment TLR4 signaling when over-produced in LPS hypersensitive gp130F/F mice. The identity of the LPS/TLR4 responsive inflammatory signaling pathways and gene networks which are modulated by IL6 ar...
ORGANISM(S): Mus musculus 
2011-05-17 | E-GEOD-29311 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human benign and malignant pheochromocytomas
Total RNA was isolated from fresh-frozen tissue of 5 benign and 5 malignant pheochromocytomas. The reference consisted of laser microdissected (LMD) tissue from normal adrenal medullae from 10 different patients. After generating Cy3- and Cy5-fluorescently labeled cDNAs, F-chips containing 11,540 s...
ORGANISM(S): Homo sapiens 
2009-07-01 | E-MEXP-2137 | biostudies-arrayexpress
GenomicsGenomes of Relapsing Neuroblastoma
Neuroblastoma is a malignancy of the developing sympathetic nervous system that is often lethal when relapse occurs, but the molecular mechanisms behind this process are poorly defined. We here used whole-exome sequencing, mRNA expression, array CGH and DNA methylation analysis to holistically chara...
EGAS00001001387 | EGA
TranscriptomicsTranscription profiling of mouse bone marrow macrophages from IL-6-/- and IL-10-/- mutants treated with IL-10 or IL-6 stimulation in the presence of LPS
IL-10 or IL-6 stimulation of control 129xC57BL/6 murine bone marrow derived macrophages in the presence of LPS. We used microarrays to detail the global programme of gene expression changes in response to IL-6 or IL-10 stimulation in the presence of lipopolysaccharide. BMDMs were isolated from cont...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5589 | biostudies-arrayexpress
Genomicsena-DATASET-UKEssen-09-09-2015-10:54:33:815-144 - samples
In this dataset, 16 trios- primary tumor, relapse and corresponding normals- for patients with neuroblastoma are provided. For one patient, more than one relapse was available for the analyses.
EGAD00001001607 | EGA
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