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TranscriptomicsTranscriptional profiling of liver tissue from mice with wild-type, N750F mutant or exon 19 deleted RB1, after treatment with diethylnitrosamine.
The LXCXE peptide motif facilitates interaction between the RB tumor suppressor and a large number of cellular proteins that are expected to impinge on diverse biological processes. In vitro and in vivo analyses demonstrated that LXCXE-binding function is dispensable for RB promoter association and...
ORGANISM(S): Mus musculus 
2011-12-01 | E-GEOD-31169 | biostudies-arrayexpress
TranscriptomicsAberrant BAF57 Signaling Facilitates Pro-metastatic Phenotypes
BAF57, a component of the SWI/SNF chromatin remodeling complex conglomerate,modulates androgen receptor activity to promote prostate cancer. However the molecular consequences of tumor associated BAF57 elevation have remianed undefined in advanced disease such as castration resistant prostate cance...
ORGANISM(S): Homo sapiens 
2013-06-04 | E-GEOD-44418 | biostudies-arrayexpress
TranscriptomicsProlactin-inducible Stat5a-mediated and Stat5b-mediated gene profiles
Stat5a and Stat5b proteins are highly homologous with greater than 90% amino acid identity and share binding to the palindromic Stat5 consensus sequence, TTCNNNGAA, but individual roles of each transcription factor in breast cancer have not been thoroughly evaluated. To determine the degree of simi...
ORGANISM(S): Homo sapiens 
2012-08-29 | E-GEOD-37781 | biostudies-arrayexpress
UnknownProlactin-inducible Stat5a-mediated and Stat5b-mediated gene profiles
Not available
ORGANISM(S): Homo sapiens 
S-ECPF-GEOD-37781 | biostudies-other
UnknownUpregulation of ERBB3 by FOXD3, an adaptive response to RAF and MEK inhibitors
Not available
ORGANISM(S): Homo sapiens 
S-ECPF-GEOD-43962 | biostudies-other
TranscriptomicsGenomic profiles of mouse liver tissue harboring deletion of RB and/or p53, untreated or post-hepatocarcinogen treatment [expression data]
The retinoblastoma (RB) and p53 tumor suppressors are critical regulators of the cell cycle with profound impact on both normal cell biology and disease etiology. In the context of human cancers, compound inactivation of RB and p53 is a frequent occurrence; however, the cooperation of these tumor su...
ORGANISM(S): Mus musculus 
2011-09-19 | E-GEOD-29846 | biostudies-arrayexpress
TranscriptomicsGenomic profiles of mouse liver tissue harboring deletion of RB and/or p53, untreated or post-hepatocarcinogen treatment [CGH data]
The retinoblastoma (RB) and p53 tumor suppressors are critical regulators of the cell cycle with profound impact on both normal cell biology and disease etiology. In the context of human cancers, compound inactivation of RB and p53 is a frequent occurrence; however, the cooperation of these tumor su...
ORGANISM(S): Mus musculus 
2011-09-19 | E-GEOD-29847 | biostudies-arrayexpress
UnknownProgression of ductal carcinoma in situ to invasive breast cancer
Not available
ORGANISM(S): Homo sapiens 
S-ECPF-GEOD-33692 | biostudies-other
TranscriptomicsRB pathway deregulation promotes invasion and disease progression in a mouse model of MYC-overexpressing mammary tumorigenesis
Breast cancer is a highly heterogeneous disease that is categorized into distinct tumor subtypes based on specific molecular attributes, which ultimately influence therapeutic options. Unlike ER+ and/or HER2+ cancers that are subject to specific targeted therapies, triple negative breast cancers (TN...
ORGANISM(S): Mus musculus 
2013-08-01 | E-GEOD-40545 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of mouse liver tissue harboring deletion of RB and/or p53, untreated or post-hepatocarcinogen treatment
This SuperSeries is composed of the following subset Series: GSE29846: Genomic profiles of mouse liver tissue harboring deletion of RB and/or p53, untreated or post-hepatocarcinogen treatment [expression data] GSE29847: Genomic profiles of mouse liver tissue harboring deletion of RB and/or p53, untr...
ORGANISM(S): Mus musculus 
2011-09-19 | E-GEOD-24347 | biostudies-arrayexpress
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