Sort   by:  
 Page size 
ProteomicsA deep-learning framework reveals whole-body perturbations at cell level
Many diseases, including obesity, have systemic effects that perturb multiple organ systems throughout the body. However, tools for comprehensive, high-resolution analysis of disease-associated changes at the whole-body scale have been lacking. Here we developed MouseMapper, a suite of foundation-mo...
ORGANISM(S): Homo sapiens (Human) 
2026-05-06 | PXD071172 | Pride
Human Brain Bruker Mouse Timstofscp Obesity Ganglion 
ProteomicsSARS-CoV-2 Spike Protein in the Skull-Meninges-Brain Axis
COVID-19 has been associated with a variety of neurological symptoms, including brain fog and brain tissue loss. This raises concerns about the virus's acute and potential chronic impacts on the brain. Using whole mouse and human tissue clearing, we determined all potential tissues targeted by the S...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2024-12-02 | PXD050384 | Pride
Covid-19 Skull Dia Meninges Brain Sars-cov-2 Lc-ms/ms 
ProteomicsA deep-learning framework reveals whole-body perturbations at cell level
Many diseases, such as obesity, have systemic effects that impact multiple organ systems throughout the body. However, tools for comprehensive, high-resolution analysis of disease-associated changes at the whole-body scale have been lacking. Here, we developed a suite of deep learning-based image an...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-06 | PXD054819 | Pride
Obesity Tissue clearing Trigeminal ganglion Imaging High-fat diet 
ProteomicsNanocarrier imaging at single-cell resolution across entire mouse bodies with deep learning
Efficient and accurate nanocarrier development for targeted drug delivery is hindered by the inability to analyze cell-level biodistribution across intact whole organisms. We introduce SCP-Nano (Single Cell Precision Nanocarrier Identification), a deep learning pipeline designed to quantify the targ...
ORGANISM(S): Mus musculus (Mouse) 
2024-12-06 | PXD056871 | Pride
Tissue clearing Single-cell resolution Whole-body imaging Ai Nanocarriers 
ProteomicsDISCO-MS: Proteomics of spatially identified tissues in whole organs and organisms
Spatial molecular profiling of complex tissues is essential to investigate cellular function in physiological and pathological states. However, methods for molecular analysis of biological specimens imaged in 3D as a whole are lacking. Here, we present DISCO-MS, a technology combining whole-organ/is...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-12-23 | PXD034027 | Pride
Disco-ms Disci-bot 
UnknownGraph neural networks learn emergent tissue properties from spatial molecular profiles.
Not available
S-EPMC12462520 | biostudies-literature
UnknownNanocarrier imaging at single-cell resolution across entire mouse bodies with deep learning.
Not available
S-EPMC12700832 | biostudies-literature
UnknownDistinct molecular profiles of skull bone marrow in health and neurological disorders.
Not available
S-EPMC10443631 | biostudies-literature
UnknownEPIdemiology of Surgery-Associated Acute Kidney Injury (EPIS-AKI): study protocol for a multicentre, observational trial.
Not available
S-EPMC8718477 | biostudies-literature
UnknownEvaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries.
Not available
S-EPMC10771257 | biostudies-literature
Sort   by:  
 Page size