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ProteomicsDISCO-MS: Proteomics of spatially identified tissues in whole organs and organisms
Spatial molecular profiling of complex tissues is essential to investigate cellular function in physiological and pathological states. However, methods for molecular analysis of biological specimens imaged in 3D as a whole are lacking. Here, we present DISCO-MS, a technology combining whole-organ/is...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-12-23 | PXD034027 | Pride
Disco-ms Disci-bot 
ProteomicsDISCO-MS: Proteomics of spatially identified tissues in whole organs
Spatial molecular profiling of complex tissues is essential to investigate cellular function in physiological and pathological states. Liquid chromatography coupled to mass spectrometry (LC-MS) is emerging as a key technology for the unbiased characterization of proteins, the drivers of cellular fun...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-11-27 | PXD025316 | Pride
Ultra-high sensitivity proteomics  proteomics  tissue-clearing  solvent-clearing  familial alzheimer’s disease  mild traumatic brain injury  imaging  spatial proteomics 
UnknownDA_2DCHROM - a data alignment tool for applications on real GC × GC-TOF samples.
Not available
S-EPMC10149467 | biostudies-literature
ProteomicsDevelopment of sequential sample processing protocol on a single anion-exchange solid-phase extraction disc for bottom-up/cross-linking mass spectrometry
In this project, we developed a rapid enzymatic digestion protocol within an anion exchange StageTip named AnExSP (anion-exchange disc-assisted sequential sample preparation) and, using data-independent acquisition, analyzed its digestion performance of human cellular protein extracts (HCPE) using t...
ORGANISM(S): Homo Sapiens (human) 
2022-04-20 | PXD029444 | JPOST Repository
ProteomicsQuantitative serum proteomic analysis for potential biomarkers in post-COVID-19 onset Postural Orthostatic Tachycardia Syndrome (PC-POTS) patients
Postural orthostatic tachycardia syndrome (POTS) is a chronic neurological disorder of the autonomic nervous system (ANS) that is characterized by an excessive increase in heart rate upon orthostatic challenge. The symptoms of POTS are often debilitating, and it primarily affects young females. Even...
ORGANISM(S): Homo sapiens (Human) 
2025-05-08 | PXD052725 | Pride
Post-acute sequelae of covid-19 Post-covid-19 syndrome Mass spectrometry Postural orthostatic tachycardia syndrome Long covid syndrome Tandem mass tag Serum proteomics Biomarker 
UnknownContribution of Rare and Low-Frequency Variants to Multiple Sclerosis Susceptibility in the Italian Continental Population.
Not available
S-EPMC8762330 | biostudies-literature
UnknownA multi-step genomic approach prioritized TBKBP1 gene as relevant for multiple sclerosis susceptibility.
Not available
S-EPMC9294010 | biostudies-literature
ProteomicsCoolTip: Low-Temperature Solid-Phase Microextraction Tip for Capturing Hydrophilic Phosphopeptides
We developed a simple temperature controlled desalting strategy to cover from hydrophilic to hydrophobic peptides. Reversed-phase solid-phase extraction (SPE) techniques are commonly used for shotgun-proteomics using liquid chromatography/tandem mass spectrometry. In reversed-phase chromatography, s...
ORGANISM(S): Homo Sapiens (human) 
2021-10-28 | PXD027112 | JPOST Repository
ProteomicsCoolTip: Low-Temperature Solid-Phase Microextraction Tip for Capturing Hydrophilic Phosphopeptides: 2
We developed a simple temperature controlled desalting strategy to cover from hydrophilic to hydrophobic peptides. Reversed-phase solid-phase extraction (SPE) techniques are commonly used for shotgun-proteomics using liquid chromatography/tandem mass spectrometry. In reversed-phase chromatography, s...
ORGANISM(S): Homo Sapiens (human) 
2021-10-28 | PXD028871 | JPOST Repository
GenomicsmodENCODE_White Lab: genome-wide ChIP data of disco from E0-8h on Illumina Genome Analyzer.
This is a dataset generated by the Drosophila Regulatory Elements modENCODE Project led by Kevin P. White at the University of Chicago. It contains genome-wide binding profile of the factor disco from E0-8h generated by ChIP and analyzed on Illumina Genome Analyzer. Keywords: Epigenetics For data u...
ORGANISM(S): Drosophila melanogaster 
2010-08-11 | E-GEOD-23144 | biostudies-arrayexpress
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