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MetabolomicsDisruption of Methionine Metabolism Drives Erythroid Cell Fate Reprogramming by Remodeling the H3K4me3 Landscape

Methionine cycle plays critical roles in cell fate determination by shaping epigenetic landscape, yet its function in human erythropoiesis remains undefined. Here, we show that disruption of methionine metabolism by compromising key enzyme adenosylhomocysteinase (AHCY) reshapes H3K4me3 landscape,...

2026-06-10 | MTBLS10469 | MetaboLights
MetabolomicsMetabolomics analysis of stress erythroid progenitors
Not available
ORGANISM(S): Mus musculus 
ST002009 | MetabolomicsWorkbench
TranscriptomicsIdentification of Biologically Relevant Enhancers in Human Erythroid Cells [Illumina BeadArray]
Identification of cell-type specific enhancers is important for understanding the regulation of programs controlling cellular development and differentiation. Enhancers are typically marked by the co-transcriptional activator protein p300 or by groups of cell-expressed transcription factors. We hypo...
ORGANISM(S): Homo sapiens 
2013-01-28 | E-GEOD-43624 | biostudies-arrayexpress
MetabolomicsIsotope tracing analysis of stress erythroid progenitors
Not available
ORGANISM(S): Mus musculus 
ST002007 | MetabolomicsWorkbench
GenomicsIdentification of Biologically Relevant Enhancers in Human Erythroid Cells [ChIP-Seq]
Identification of cell-type specific enhancers is important for understanding the regulation of programs controlling cellular development and differentiation. Enhancers are typically marked by the co-transcriptional activator protein p300 or by groups of cell-expressed transcription factors. We hypo...
ORGANISM(S): Homo sapiens 
2013-01-28 | E-GEOD-43625 | biostudies-arrayexpress
MetabolomicsMetabolomics analysis of stress erythroid progenitors (Part 2)
Not available
ORGANISM(S): Mus musculus 
ST002499 | MetabolomicsWorkbench
GenomicsGenome-wide ChIP-Seq reveals a dramatic shift in the binding of the transcription factor erythroid Kruppel-like factor during erythrocyte differentiation
Erythropoiesis is dependent on the activity of transcription factors, including the erythroid-specific erythroid Kruppel-like factor (EKLF). ChIP followed by massively parallel sequencing (ChIP-Seq) is a powerful, unbiased method to map transfactor occupancy. We used ChIP-Seq to study the interactom...
ORGANISM(S): Mus musculus 
2013-06-17 | E-GEOD-48020 | biostudies-arrayexpress
TranscriptomicsKLF2-Regulated Gene Expression in Mouse Embryonic Yolk Sac Erythroid Cells
KLF2 is a Krüppel-like zinc-finger transcription factor required for blood vessel, lung, T-cell, and erythroid development. KLF2-/- mice die by embryonic day 14.5 (E14.5), due to hemorrhaging and heart failure. Embryonic -like globin gene expression is reduced in KLF2-/- embryos compared to wildtype...
ORGANISM(S): Mus musculus 
2011-03-02 | E-GEOD-27602 | biostudies-arrayexpress
GenomicsKLF1/EKLF regulatory networks in primary erythroid cells
KLF1 (EKLF) regulates a diverse suite of genes to direct erythroid cell differentiation from bi-potent progenitors. To determine the local cis-regulatory contexts and transcription factor networks in which KLF1 operates, we performed KLF1 ChIP-seq in the mouse. We found at least 945 sites in the gen...
ORGANISM(S): Mus musculus 
2010-04-08 | E-GEOD-20478 | biostudies-arrayexpress
TranscriptomicsDynamic transcriptomes during human erythroid differentiation and development
To explore the mechanisms controlling erythroid differentiation and development in human, we analyzed the genome-wide transcription dynamics that occurs during the differentiation of HESCs into the erythroid lineage and development of embryonic to adult erythropoiesis using high throughput sequencin...
ORGANISM(S): Homo sapiens 
2013-10-31 | E-GEOD-32991 | biostudies-arrayexpress
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