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ProteomicsPALB2 ChAM acetylation mapping in human cells
The Chromatin Association Motif (ChAM) of the PArtner and Localizer of BRCA2 (PALB2) is essential for DNA repair function by homologous recombination in human cells. Molecular mechanisms governing ChAM interaction with chromatin remain unexplored. In this study, we have mapped acetylated lysines wit...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD014678 | Pride
Acetylation Dna repair Chromatin 
ProteomicsPALB2 acetylation by KAT2A/B (GCN5/PCAF) in vitro
PArtner and Localizer of BRCA2 (PALB2) is essential to maintain genome stability in human cells. Upon DNA damage by double DNA strand breaks, PALB2 is required to repair DNA by homologous recombination. In undamaged conditions, PALB2 protects coding regions, by preventing DNA stress due to collision...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD014681 | Pride
Acetylation Dna repair 
ProteomicsPALB2 interactome in asynchronous human cells
Identification of interacting partners of the Partner and Localizer of BRCA2 (PALB2), essential regulator of DNA repair by homologous recombination. Interacting partners of PALB2 were purified by GFP pull down from asynchronous HEK293 Flp-In T-REx cells, exogenously expressing Flag-EGFP tagged PALB2...
ORGANISM(S): Homo sapiens (Human) 
2017-07-18 | PXD006391 | Pride
Dna repair Genomic stability 
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