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GenomicsESCRT-I controls lysosomal membrane protein homeostasis and restricts MCOLN1-dependent TFEB/TFE3 signaling.
ESCRT-I controls lysosomal membrane protein homeostasis and restricts MCOLN1-dependent TFEB/TFE3 signaling.
PRJNA739978 | ENA
TranscriptomicsESCRT-I controls lysosomal membrane protein homeostasis and restricts MCOLN1-dependent TFEB/TFE3 signaling.
Within the endolysosomal pathway in mammalian cells, ESCRT complexes facilitate degradation of membrane proteins from limiting membranes of late endosomes. Recent studies revealed that yeast ESCRT proteins also sort for degradation, ubiquitinated proteins from vacuolar membrane. However, whether mam...
ORGANISM(S): Homo sapiens 
2022-03-28 | GSE178665 | GEO
ProteomicsIdentification of ESCRT-related subunits in Trypanosoma brucei
Using cryomilling and proteomics approaches we expand the understanding of ESCRT-I complex in Trypanosoma brucei. We found two novel subunits of the trypanosoma complex using TbVPS23 as bait.
ORGANISM(S): Trypanosoma brucei 
2026-08-24 | PXD058826 | Pride
Trypanosoma Co-immunoprecipitation Vps23 Cryomilling Escrt-i (endosomal sorting complex required for transport-i) 
UnknownComparative analysis of ESCRT-I, ESCRT-II and ESCRT-III function in Drosophila by efficient isolation of ESCRT mutants.
Not available
S-EPMC2704878 | biostudies-literature
GenomicsConcurrent depletion of Vps37 proteins evokes inflammatory response and cell growth inhibition via ESCRT-I destabilization.
Concurrent depletion of Vps37 proteins evokes inflammatory response and cell growth inhibition via ESCRT-I destabilization.
PRJNA638612 | ENA
UnknownEfficient cargo sorting by ESCRT-I and the subsequent release of ESCRT-I from multivesicular bodies requires the subunit Mvb12.
Not available
S-EPMC1783790 | biostudies-literature
UnknownStructural basis for endosomal recruitment of ESCRT-I by ESCRT-0 in yeast.
Not available
S-EPMC3117643 | biostudies-literature
UnknownESCRT-III activation by parallel action of ESCRT-I/II and ESCRT-0/Bro1 during MVB biogenesis.
Not available
S-EPMC4865371 | biostudies-literature
TranscriptomicsConcurrent depletion of Vps37 proteins evokes inflammatory response and cell growth inhibition via ESCRT-I destabilization.
Ample evidence points to the contribution of endocytosis to oncogenesis at the cellular level but molecular details still remain obscure. Our analysis of The Cancer Genome Atlas data involving cohorts of colorectal cancer (CRC) patients revealed stage-dependent alterations in the expression of 113 g...
ORGANISM(S): Homo sapiens 
2020-12-17 | GSE152195 | GEO
UnknownALIX and ESCRT-I/II function as parallel ESCRT-III recruiters in cytokinetic abscission.
Not available
S-EPMC4772496 | biostudies-literature
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