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ProteomicsPTPN23-dependent ESCRT machinery functions as a cell death checkpoint in restraining multiple cell death pathways
In our study, a CRISPR screen of acute myeloid leukemia cells identifies protein tyrosine phosphatase non-receptor type 23 (PTPN23) as essential for survival. Loss of PTPN23 activates nuclear factor-kappa B, apoptotic, necroptotic, and pyroptotic pathways by causing the accumulation of death recepto...
ORGANISM(S): Homo Sapiens 
PXD056836 |
UnknownNew component of ESCRT-I regulates endosomal sorting complex assembly.
Not available
S-EPMC2064680 | biostudies-literature
UnknownIdentification of the endosomal sorting complex required for transport-I (ESCRT-I) as an important modulator of anti-miR uptake by cancer cells.
Not available
S-EPMC4333411 | biostudies-literature
UnknownESCRT-I mediates FLS2 endosomal sorting and plant immunity.
Not available
S-EPMC3873229 | biostudies-literature
ProteomicsIdentification of ESCRT-related subunits in Trypanosoma brucei
Using cryomilling and proteomics approaches we expand the understanding of ESCRT-I complex in Trypanosoma brucei. We found two novel subunits of the trypanosoma complex using TbVPS23 as bait.
ORGANISM(S): Trypanosoma brucei 
2026-08-24 | PXD058826 | Pride
Trypanosoma Co-immunoprecipitation Vps23 Cryomilling Escrt-i (endosomal sorting complex required for transport-i) 
UnknownRegulation of cargo transfer between ESCRT-0 and ESCRT-I complexes by flotillin-1 during endosomal sorting of ubiquitinated cargo.
Not available
S-EPMC5519196 | biostudies-literature
UnknownTANK-binding kinase 1 attenuates PTAP-dependent retroviral budding through targeting endosomal sorting complex required for transport-I.
Not available
S-EPMC4309384 | biostudies-literature
UnknownEfficient cargo sorting by ESCRT-I and the subsequent release of ESCRT-I from multivesicular bodies requires the subunit Mvb12.
Not available
S-EPMC1783790 | biostudies-literature
UnknownDynamics of endosomal sorting complex required for transport (ESCRT) machinery during cytokinesis and its role in abscission.
Not available
S-EPMC3064317 | biostudies-literature
UnknownEndofin is required for HD-PTP and ESCRT-0 interdependent endosomal sorting of ubiquitinated transmembrane cargoes.
Not available
S-EPMC8567383 | biostudies-literature
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