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TranscriptomicsGene expression profiling of mouse p53-deficient epidermal carcinoma defines molecular determinants of human cancer malignancy (testing dataset)
The epidermal specific ablation of Trp53 gene leads to the spontaneous development of aggressive tumors in mice through a process that is accelerated by the simultaneous ablation of Rb gene. Since alterations of p53-dependent pathway are common hallmarks of aggressive, poor prognostic human cancers,...
ORGANISM(S): Mus musculus 
2010-07-20 | E-GEOD-19616 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of mouse p53-deficient epidermal carcinoma defines molecular determinants of human cancer malignancy (training dataset)
The epidermal specific ablation of Trp53 gene leads to the spontaneous development of aggressive tumors in mice through a process that is accelerated by the simultaneous ablation of Rb gene. Since alterations of p53-dependent pathway are common hallmarks of aggressive, poor prognostic human cancers,...
ORGANISM(S): Mus musculus 
2010-07-20 | E-GEOD-11990 | biostudies-arrayexpress
ProteomicsGenomic exaptation and regulatory landscape shifts as key mechanisms enabling flatworm terrestrialization
Understanding the genomic toolkit that enabled animal terrestrialization, the shift from aquatic to terrestrial habitats, is key to uncovering the evolutionary origins of land biodiversity. Yet, the genomic basis of the physiological and metabolic adaptations required for life on land remains poorly...
ORGANISM(S): Obama nungara Schmidtea mediterranea (Freshwater planarian flatworm) 
2026-04-06 | PXD074775 | Pride
Planarians Evolution Flatworm Terrestrialization 
ProteomicsLack of a universal genomic toolkit for animal terrestrialisation
Animal terrestrialisation, the transition from aquatic to land environments, is one of the most impactful events in animal evolution, having occurred independently across several phyla. Yet, whether these transitions relied on a conserved genomic toolkit remains unexplored. To address this gap, we i...
ORGANISM(S): Obama nungara Siphonaria pectinata Leptonemertes chalicophora Lineus sanguineus Schmidtea mediterranea (Freshwater planarian flatworm) Litoditis marina Eisenia fetida Phorcus turbinatus Caenorhabditis elegans Theba pisana Porcellio scaber Ligia oceanica Physella Hirudo medicinalis Arenicola marina Ooperipatellus viridimaculatus 
2026-06-15 | PXD064337 | Pride
Proteomics Terrestrialization 
UnknownThe biochemical pattern defines MASLD phenotypes linked to distinct histology and prognosis.
Not available
S-EPMC11217049 | biostudies-literature
TranscriptomicsIn vivo disruption of Rb-E2F-Ezh2 signaling loop causes bladder cancer development
Bladder cancer (BC) is a highly prevalent human disease in which Rb pathway inactivation and epigenetic alterations are common events. However, the connection between these two processes is still poorly understood. Here we show that the in vivo inactivation of all Rb family genes in the mouse urothe...
ORGANISM(S): Homo sapiens 
2014-10-02 | E-GEOD-38264 | biostudies-arrayexpress
UnknownProspective Biomarker Study in Advanced RAS Wild-Type Colorectal Cancer: POSIBA Trial (GEMCAD 10-02).
Not available
S-EPMC6853109 | biostudies-literature
UnknownCoexpression of p-IGF-1R and MMP-7 Modulates Panitumumab and Cetuximab Efficacy in RAS Wild-Type Metastatic Colorectal Cancer Patients.
Not available
S-EPMC6030389 | biostudies-literature
TranscriptomicsA mouse model of deregulation of the malt1 oncogene recapitulates the pathogenesis of human malt lymphoma [MALT dataset]
Attempts at modeling chromosomal translocations involving MALT1 gene, hallmarks of human mucosa-associated lymphoid tissue (MALT) lymphoma, have failed to reproduce the disease in mice. Here we describe a transgenic model in which MALT1 expression was targeted to mouse hematopoietic stem/progenitor ...
ORGANISM(S): Homo sapiens 
2012-07-09 | E-GEOD-25638 | biostudies-arrayexpress
TranscriptomicsA mouse model of deregulation of the malt1 oncogene recapitulates the pathogenesis of human malt lymphoma [MouseSca1 dataset]
Attempts at modeling chromosomal translocations involving MALT1 gene, hallmarks of human mucosa-associated lymphoid tissue (MALT) lymphoma, have failed to reproduce the disease in mice. Here we describe a transgenic model in which MALT1 expression was targeted to mouse hematopoietic stem/progenitor ...
ORGANISM(S): Mus musculus 
2012-07-09 | E-GEOD-25636 | biostudies-arrayexpress
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