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MetabolomicsLipidomics of esophageal adenocarcinoma
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ORGANISM(S): Homo sapiens 
ST001942 | MetabolomicsWorkbench
TranscriptomicsProcessed small RNA sequencing data of healthy and disease tissue samples from patients with esophageal adenocarcinoma or precursor lesions
In the past decades, the incidence of esophageal adenocarcinoma has increased dramatically in Western populations. Better understanding of disease etiology along with the identification of novel prognostic and predictive biomarkers are urgently needed to improve the dismal survival probabilities. He...
ORGANISM(S): Homo sapiens 
2022-01-01 | E-MTAB-10003 | biostudies-arrayexpress
MetabolomicsDesorption electrospray ionisation mass spectrometry imaging of esophageal lymph mode metastases
Lymph node metastases (LNM) and primary tumour samples were analysed using desorption electrospray ionisation mass spectrometry imaging (DESI MSI). Current assessment of LNM depends on subjective histopathological assessment, whereas analysis by DESI MSI permits an entirely objective assessment. The...
2017-01-10 | MTBLS385 | MetaboLights
TranscriptomicsWhole transcriptome profiling of Esophageal adenocarcinoma and Barrett's
RNA-seq was performed on esophageal adenocarcinoma (EAC), Barrett's without dysplasia, Barrett's with low-grade dysplasia (LGD) and normal squamous esophagus tissue to find early alterations in the transcriptome level turning Barrett's dysplastic.
ORGANISM(S): Homo sapiens 
2017-07-23 | E-MTAB-4054 | biostudies-arrayexpress
TranscriptomicsIntegrated analysis of genome-wide copy number and matched expression data reveals novel genes in esophageal adenocarcinoma
The incidence of esophageal and junctional adenocarcinoma has increased 6-fold in the west in the last 30 years and 5 year survival remains <14%. We aimed to characterize genome-wide aberrations in esophageal adenocarcinoma to further understand disease pathogenesis and ultimately identify groups wi...
ORGANISM(S): Homo sapiens 
2011-05-09 | E-GEOD-25201 | biostudies-arrayexpress
TranscriptomicsPaired non-cancerous and cancerous miRNA expression of esophageal adenocarcinoma and squamous cell carcinoma patients
Identifying biomarkers predictive for early esophageal cancer detection is critical considering the dismal survival rates. We investigated the involvement of microRNAs (miRNAs), their utility as biomarkers, and their association with survival in esophageal cancer, including Barrett’s associated and...
ORGANISM(S): Homo sapiens 
2010-07-09 | E-GEOD-13937 | biostudies-arrayexpress
TranscriptomicsHuman esophageal adenocarcinomas
The incidence of esophageal and junctional adenocarcinoma has increased 6 fold in the last 30 years and 5 year survival remains less than 14%. Most patients present with advanced disease and current staging is limited in its ability to predict survival. We aimed to generate and validate a molecular ...
ORGANISM(S): Homo sapiens 
2010-06-01 | E-GEOD-19417 | biostudies-arrayexpress
TranscriptomicsProcessed polyA+ RNA sequencing data of tissue samples from patients with esophageal adenocarcinoma or precursor lesions
In the past decades, the incidence of esophageal adenocarcinoma has increased dramatically in Western populations. Better understanding of disease etiology along with the identification of novel prognostic and predictive biomarkers are urgently needed to improve the dismal survival probabilities. He...
ORGANISM(S): Homo sapiens 
2022-01-01 | E-MTAB-10005 | biostudies-arrayexpress
TranscriptomicsProcyanidin-induced apoptosis of esophageal adenocarcinoma cells is mediated via stress-activated protein kinase activation of JUN-dependent transcription.
Epidemiologic studies have shown a significant inverse correlation between fruit and vegetable consumption and incidence of esophageal adenocarcinoma. Procyanidins are polymeric flavanols found in many fruits and vegetables, and have been shown to possess anti-carcinogenic/chemopreventive properties...
ORGANISM(S): Homo sapiens 
2011-06-16 | E-MEXP-2993 | biostudies-arrayexpress
TranscriptomicsRobust prognostic biomarkers for EAC identified by systems-level characterization of tumor transcriptome
Despite continual efforts to rationalize a prognostic stratification of patients with esophageal adenocarcinoma (EAC) before treatment, current staging system only shows limited success owing to the lack of molecular and genetic markers that reflect prognostic features of the tumor. To develop molec...
ORGANISM(S): Homo sapiens 
2011-01-04 | E-GEOD-13898 | biostudies-arrayexpress
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