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ProteomicsMDM2-amplified esophageal adenocarcinomas exhibit an activated metabolic and immunosuppressive phenotype with multiple potential therapeutic targets
A complete response following neoadjuvant therapy occurs only in a fraction of patients with esophageal adenocarcinoma (EAC). Further targeted treatment options are needed to improve treatment response and patient survival. Mouse double minute 2 homolog (MDM2) is a known oncogene. Its upregulation r...
ORGANISM(S): Homo sapiens (Human) 
2025-12-15 | PXD058762 | Pride
Esophageal adenocarcinomas Tumor microenvironment Met signaling pathway Oncology Proteomics 
TranscriptomicsAffymetrix 250K StyI SNP array data for gastric and esophageal adenocarcinoma cancer types
Using data from high-density genomic profiling arrays, we describe the profiles of somatic copy-number aberrations (SCNAs) in 486 adenocarcinomas across all three major digestive organs, including 296 gastric and esophageal cancers. This analysis revealed that although patterns of broad, chromosome ...
ORGANISM(S): Homo sapiens 
2012-09-04 | E-GEOD-36459 | biostudies-arrayexpress
TranscriptomicsAffymetrix SNP 6.0 array data for colon, gastric and esophageal adenocarcinoma cancer types
Using data from high-density genomic profiling arrays, we describe the profiles of somatic copy-number aberrations (SCNAs) in 486 adenocarcinomas across all three major digestive organs, including 296 gastric and esophageal cancers. This analysis revealed that although patterns of broad, chromosome ...
ORGANISM(S): Homo sapiens 
2012-09-04 | E-GEOD-36458 | biostudies-arrayexpress
TranscriptomicsHuman esophageal adenocarcinomas
The incidence of esophageal and junctional adenocarcinoma has increased 6 fold in the last 30 years and 5 year survival remains less than 14%. Most patients present with advanced disease and current staging is limited in its ability to predict survival. We aimed to generate and validate a molecular ...
ORGANISM(S): Homo sapiens 
2010-06-01 | E-GEOD-19417 | biostudies-arrayexpress
TranscriptomicsSOX15 governs a transcriptional program in human esophageal stratified epithelium and in a subset of esophageal adenocarcinomas
We identified spatially restricted transcription factors and found SOX15 expression confined to stratified esophageal epithelium, with attenuation in Barrett's esophagus. SOX15 binds esophagus-specific loci and its loss in human esophageal cells affected esophagus-specific transcripts [RNA-Seq] Tota...
ORGANISM(S): Homo sapiens 
2015-11-09 | E-GEOD-62909 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of esophagus samples from eight human patients with Barretts associated adenocarcinomas
Samples were obtained from 8 patients with Barrett's associated adenocarcinomas after transhiatal esophagectomy. Samples representative of the normal esophageal epithelium (N), Barrett’s esophagus (B) and esophageal adenocarcinomas (ADC) were obtained from every patient by experienced GI pathol...
ORGANISM(S): Homo sapiens 
2007-08-06 | E-GEOD-1420 | biostudies-arrayexpress
ProteomicsProteomic Characterization of MET-Amplified Esophageal Adenocarcinomas Reveals Enrichment of Alternative Splicing- and Androgen Signaling-Related Proteins
Background Esophageal adenocarcinomas (EACs) represent an evolving tumor entity with high mortality rates. MET amplification is a recurrent driver in EACs and is associated with decreased patient survival. However, the response to MET inhibitors is limited. Recent studies have identified several mec...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD059513 | Pride
Esophageal adenocarcinomas Tumor microenvironment Met signaling pathway Oncology Proteomics 
ProteomicsAdherens junction protein expression is associated with poor response to neoadjuvant FLOT chemotherapy and pro-inflammatory tumor microenvironment in esophageal adenocarcinoma
Esophageal adenocarcinomas represent aggressive gastrointestinal malignancies, characterized by poor survival and variable responses to perioperative therapies. Our study identified a significant association between adherens junction (AJ) protein expression and treatment response to FLOT chemotherap...
ORGANISM(S): Homo sapiens (Human) 
2026-01-06 | PXD071328 | Pride
Esophageal adenocarcinoma Flot perioperative treatment Cell adhesion Tumor microenvironment 
TranscriptomicsGastrointestinal Adenocarcinomas of the Esophagus, Stomach, and Colon Exhibit Distinct Patterns of Genome Instability and Oncogenesis.
This SuperSeries is composed of the following subset Series: GSE36458: Affymetrix SNP 6.0 array data for colon, gastric and esophageal adenocarcinoma cancer types GSE36459: Affymetrix 250K StyI SNP array data for gastric and esophageal adenocarcinoma cancer types Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-08-31 | E-GEOD-36460 | biostudies-arrayexpress
TranscriptomicsPaired non-cancerous and cancerous miRNA expression of esophageal adenocarcinoma and squamous cell carcinoma patients
Identifying biomarkers predictive for early esophageal cancer detection is critical considering the dismal survival rates. We investigated the involvement of microRNAs (miRNAs), their utility as biomarkers, and their association with survival in esophageal cancer, including Barrett’s associated and...
ORGANISM(S): Homo sapiens 
2010-07-09 | E-GEOD-13937 | biostudies-arrayexpress
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