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MetabolomicsSOX2 Drives Esophageal Squamous Carcinoma by Reprogramming Lipid Metabolism and Histone Acetylation Landscape

SOX2 is not only a pioneer transcription factor with critical roles in stem cell function and cell reprogramming but also a potent oncogene for a multitude of squamous cancers. How SOX2 exerts a potent oncogenic activity in squamous lineage is largely unknown. Here we uncovered SOX2 a p...

2025-08-07 | MTBLS7120 | MetaboLights
MetabolomicsLipidomics of esophageal adenocarcinoma
Not available
ORGANISM(S): Homo sapiens 
ST001942 | MetabolomicsWorkbench
ProteomicsProteome analysis of human serum from the esophageal cancer patient before preoperative chemoradiotherapy
To identify a biomarker that can predict the response of preoperative chemoradiotherapy (PCRT). Twenty-five serum samples from patents with esophageal cancer before PCRT (responder = 13, non-responder = 12) were analyzed by quantitative proteomics.
ORGANISM(S): Homo Sapiens (human) 
2020-02-21 | PXD012819 | JPOST Repository
ProteomicsPotential proteins identification for stent restenosis induced by esophageal benign hyperplasia in esophageal cancer
This study was conducted to explore the potential proteins associated with esophagus benign hyperplasia induced by esophageal stents.
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD014242 | Pride
Proteomics Esophageal cancer Esophagus restenosis Esophageal stents placement 
TranscriptomicsOverall aiEMT in non-cancerous samples of esophageal cancer patients
Surgical samples have long been used as important subjects for cancer research. In accordance with an increase of neoadjuvant therapy, biopsy samples have recently become imperative for cancer transcriptome. On the other hand, both biopsy and surgical samples are available for expression profiling f...
ORGANISM(S): Homo sapiens 
2011-10-06 | E-GEOD-32700 | biostudies-arrayexpress
TranscriptomicsOverall aiEMT in surgical samples of esophageal cancer patients
Surgical samples have long been used as important subjects for cancer research. In accordance with an increase of neoadjuvant therapy, biopsy samples have recently become imperative for cancer transcriptome. On the other hand, both biopsy and surgical samples are available for expression profiling f...
ORGANISM(S): Homo sapiens 
2011-10-19 | E-GEOD-33103 | biostudies-arrayexpress
TranscriptomicsIndividual aiEMT in surgical samples of esophageal cancer patients
Surgical samples have long been used as important subjects for cancer research. In accordance with an increase of neoadjuvant therapy, biopsy samples have recently become imperative for cancer transcriptome. On the other hand, both biopsy and surgical samples are available for expression profiling f...
ORGANISM(S): Homo sapiens 
2011-10-06 | E-GEOD-32701 | biostudies-arrayexpress
TranscriptomicsArtificially induced epithelial-mesenchymal transition in surgical subjects: its implications in clinical and basic cancer research
This SuperSeries is composed of the following subset Series: GSE32700: Overall aiEMT in non-cancerous samples of esophageal cancer patients GSE32701: Individual aiEMT in surgical samples of esophageal cancer patients Refer to individual Series
ORGANISM(S): Homo sapiens 
2011-10-06 | E-GEOD-22954 | biostudies-arrayexpress
TranscriptomicsProcessed small RNA sequencing data of healthy and disease tissue samples from patients with esophageal adenocarcinoma or precursor lesions
In the past decades, the incidence of esophageal adenocarcinoma has increased dramatically in Western populations. Better understanding of disease etiology along with the identification of novel prognostic and predictive biomarkers are urgently needed to improve the dismal survival probabilities. He...
ORGANISM(S): Homo sapiens 
2022-01-01 | E-MTAB-10003 | biostudies-arrayexpress
TranscriptomicsPeriostin, a cell adhesion molecule, facilitates invasion in the tumor microenvironment and annotates a novel tumor invasive signature in esophageal cancer
Human squamous cell cancers are the most common epithelially derived malignancies. One example is esophageal squamous cell carcinoma (ESCC), which is associated with a high mortality rate that is related to a propensity for invasion and metastasis. We report that periostin, a highly expressed cell a...
ORGANISM(S): Homo sapiens 
2010-07-08 | E-GEOD-21293 | biostudies-arrayexpress
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