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MetabolomicsAberrant accumulation of cyclin D1 rewires glutamine metabolism via loss of IDH3 generating metabolic vulnerability in ESCC and HNSCC

Excessive cyclin D1 accumulation is a frequent oncogenic event in head and neck squamous cell carcinoma (HNSCC) and esophageal squamous cell carcinoma (ESCC). Although classically associated with enhanced proliferation and genomic instability, we reveal that cyclin D1 dysregulation induces unexpe...

2026-08-24 | MTBLS13687 | MetaboLights
TranscriptomicsAnalysis of genomic instability in esophageal squamous cell carcinoma (ESCC)
To characterize genomic instability in esophageal squamous cell carcinoma, we examined loss of heterozygosity, copy number loss, and copy number gain in ESCC patients from a high-risk region of China. Affymetrix SNP arrays were performed according to the manufacturer's directions on DNA extracted fr...
ORGANISM(S): Homo sapiens 
2010-04-10 | E-GEOD-15526 | biostudies-arrayexpress
TranscriptomicsGene expression signatures and pathway analysis of esophageal squamous cell carcinoma
We identified a number of deregulated genes through transcriptome analysis on esophageal squamous cell carcinoma (ESCC) and adjacent normal tissues. Our pathway enrichment analysis suggested that deregulated genes were strongly enriched in multiple functionally linked pathways known to be important ...
ORGANISM(S): Homo sapiens 
2016-07-24 | E-GEOD-77531 | biostudies-arrayexpress
TranscriptomicsIdentification of a methylome signature of esophageal squamous cell carcinoma
Background & Aims: Esophageal squamous cell carcinoma (ESCC) is believed to arise from esophageal mucosa through accumulation of both genetic and epigenetic changes. DNA methylation is a critical epigenetic mechanism involved in key cellular processes and its deregulation has been linked to many hum...
ORGANISM(S): Homo sapiens 
2011-11-23 | E-GEOD-26784 | biostudies-arrayexpress
TranscriptomicsAnalysis of gene expression in esophageal squamous cell carcinoma (ESCC)
To characterize gene expression in esophageal squamous cell carcinoma, we examined gene expression in tumor and matched normal adjacent tissue from 17 ESCC patients from a high-risk region of China. RNA was extracted from 17 micro-dissected tumor and matched normal tissue pairs using the PureLink Mi...
ORGANISM(S): Homo sapiens 
2011-03-15 | E-GEOD-20347 | biostudies-arrayexpress
TranscriptomicsIdentification of a Novel Angiogenesis and Tumor Suppressor Gene Rab25 in Esophageal Squamous Cell Carcinoma
Twelve clinical samples from human esophageal squamous cell carcinoma (ESCC) (seven tumors and five non-tumors) were sequenced using Illumina high-throughput sequencing and the RNA-Seq profiling was investigated with 1730 genes significantly differentially expressed. The gene Rab25 was found to be d...
ORGANISM(S): Homo sapiens 
2012-12-05 | E-GEOD-32424 | biostudies-arrayexpress
TranscriptomicsAffymetrix SNP array data for esophageal squamous cell carcinoma (ESCC) samples
We demonstrate that blood and esophageal tissues shared similar DNA methylation patterns within the same individual,suggesting an influence of genetic background on DNA methylation. Recent studies have shown a genetic influence on gene expression variation, chromatin, and DNA methylation. However,...
ORGANISM(S): Homo sapiens 
2010-08-02 | E-GEOD-20123 | biostudies-arrayexpress
TranscriptomicsDistinctive microRNA profiles relating to patient survival in esophageal squamous cell carcinoma
We have investigated expressed microRNA in cryo-preserved esophageal cancer tissues using advanced microRNA microarray techniques. Our microarray analyses reveal a unique microRNA expression signature composed of 40 genes which can distinguish normal from malignant esophageal tissue. Some microRNA...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-6188 | biostudies-arrayexpress
TranscriptomicsDermatan sulfate is involved in the tumorigenic properties of Esophagus Squamous Cell Carcinoma
Extracellular matrix, either produced by cancer cells or by cancer-associated fibroblasts, influences angiogenesis, invasion and metastasis. Chondroitin/dermatan sulfate (CS/DS) proteoglycans, which occur both in the matrix and at the cell surface, play important roles in these processes. The unique...
ORGANISM(S): Homo sapiens 
2012-05-02 | E-GEOD-27040 | biostudies-arrayexpress
Transcriptomicsthe whole-genome methylation profile of esophageal squamous cell carcinoma
Both genetic and epigenetic aberrations are linked by intricate crosstalk, and can either individually or in synergy lead to the development of cancer. Accumulating evidence suggests that epigenetic changes such as alterations in DNA methylation play a crucial role in ESCC. We performed a Illumina I...
ORGANISM(S): Homo sapiens 
2014-11-03 | E-GEOD-52826 | biostudies-arrayexpress
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